Abstract: Objective〖HTSS〗To observe the relationship between lipoprotein a［Lp(a)］ and left ventricular thrombosis after acute anterior wall myocardial infarction.
〖WTHZ〗Methods〖HTSS〗The patients who were admitted to our hospital for the first acute anterior wall myocardial infarction and underwent emergency coronary interventional therapy were divided into non-thrombotic group and thrombotic group according to the transthoracic echocardiographic examination. Gender, age, Lp(a), left ventricular diastolic diameter and left ventricular ejection fraction(LVEF) were analyzed and compared between the two groups.
〖WTHZ〗Results〖HTSS〗A total of 284 patients, aged 38-89 years, with an average age of (71.7±7.4) years, were enrolled, and 19 cases(6.69%) of them developed left ventricular thrombosis. Patients with left ventricular thrombus had higher Lp (a) longer time from attack to reperfusion, higher peak creatine kinase level, lower ejection fraction, lower frequency of TIMI 3 flow post PCI than patients without left ventricular thrombus(all P＜0.01). Multivariable logistic regression models estimated that the Lp(a), peak creatine kinase level, time from attack to reperfusion, impaired LVEF，abnormal TIMI-flow post PCI were positive predictor of left ventricular thrombus.
〖WTHZ〗Conclusion〖HTSS〗Elevated serum level of Lp(a) (≥300 mg/L) is an independent risk factor for left ventricular thrombosis after acute anterior wall myocardial infarction.

Key words: anterior wall myocardial infarction, lipoprotein(a), thrombosis