Abstract: Objective  To explore the relationship between the activity of butyrylcholinesterase(BChE) and inflammatory factors and prognosisin in patients with acute myocardial infarction(AMI).
Methods  Eighty-three inpatients with AMI treated in the hospital were selected as the subjects. According to the different activity of BChE in serum, they were divided into low-activity BChE group and high-activity BChE group. The cardiac function was graded and left ventricular function(LVEF), serum high sensitivity C- reactive protein(hs-CRP), interleukin -6(IL-6) and tumor necrosis factor α(TNF-α) were determined. The prognosis was collected.
Results  There was no significant difference in the grade of cardiac function between two groups(P＞0.05), but the LVEF of low-activity BChE group was smaller than that of high-activity BChE group(P＜0.05). The levels of hs-CRP, IL-6 and TNF-α were significantly higher in low-activity BChE group than in high-activity BChE group(P＜0.05). The activity of BChE was positively correlated with LVEF（r=0.356， P＜0.05）, and negatively correlated with hs-CRP, IL-6 and TNF-α（r=-0.348， -0.316， -0.333，P＜0.05）. Logistic multivariate analysis of the prognosis of the patients showed that BChE activity was an independent factor affecting the prognosis of patients with myocardial infarction.
Conclusion  The activity of BChE can be used as a predictor of cardiac function in patients with myocardial infarction. The mechanism may be predicting the prognosis by reflecting the inflammatory level after myocardial infarction.

Key words: myocardial infarction, butyrylcholinesterase, inflammation