Abstract: Objective  To explore the clinical features of hemorrhagic transformation (HT) after acute cerebral infarction (ACI), and to the analyze risk factors of prognosis.
Methods  The clinical features of 40 HT patients who were admitted to the hospital were retrospectively analyzed. According to different prognosis of HT patients, they were divided into good group(22 cases) and bad group(18 cases). The clinical case data in both groups were retrospectively collected. The risk factors that affected prognosis of patients were analyzed.
Results  The clinical features of HT: In HT patients, lobe infarction, large area infarction and cardioembolism(CE) accounted for 52.50% 65.00% and 62.50%, respectively. The occurrence of HT at 8-14 d after onset accounted for 57.50%. The patients with hemorrhagic infarction(HI) and parenchyma haematoma(PH) accounted for 90.00% and 10.00%, respectively. After HT, the patients with symptom aggravation accounted for 42.50%. The Results   of univariate analysis showed that stroke history, gender, age, score of National Institutes of Health Stroke Scale (NIHSS) and taking anticoagulants were related with prognosis(P＜0.05). The Results   of multivariate analysis showed that NIHSS scores higher than 12 points and taking anticoagulants were independent risk factors of prognosis(P＜0.05). 
Conclusion  Patients with lobe infarction, large area infarction and ACI of CE type are more likely to be accompanied with HT. HT mostly occurs at 8-14 d after after ACI, most of which is HI type. There is no symptom aggravation in most of patients. NIHSS score higher than 12 points and taking anticoagulants are independent risk factor of prognosis in HT patients.

Key words: cerebral infarction, cerebral hemorrhage, prognosis