Abstract: Objective  To study the relationship between hormone levels and plasma CTRP3, immunoglobulin levels and coronary plaque stability in premenopausal women with coronary atherosclerotic heart disease（CHD）.
  Methods  The subjects of this study were 50 premenopausal women with coronary heart disease, and 25 healthy premenopausal women treated in our hospital during the same period as the control group. The relationship between hormone levels and plasma CTRP3, immunoglobulin levels and coronary plaque stability in premenopausal women with CHD were analyzed.
  Results  The levels of CTRP3, IgA, IgM, IgG， E2, FSH and LH in the observation group were significantly lower than those in the control group, with statistical significance(P＜0.05).The levels of CTRP3, IgA, IgM, IgG, E2, FSH and LH in the observation group were in turn as the control group, stable angina group and acute coronary syndrome group, with the middle thickness of the artery, plaque surface（P＜0.05）. The area and number of plaques were significantly higher than those in the control group（P＜0.05）. From the analysis of the results of two comparisons, the order of plaque stability from high to low was the control group, stable angina pectoris group and acute coronary syndrome group（P＜0.05）. The levels of E2, FSH and LH were positively correlated with the thickness of middle arterial layer, plaque area, plaque number, CTRP3, IgA, IgM and IgG levels, respectively（P＜0.05）.
  Conclusion  Hormone levels in premenopausal women with CHD are correlated with plasma CTRP3, immunoglobulin levels and coronary plaque stability. It is suggested that sex hormone levels should be used as one of the indicators of the severity of CHD in clinical diagnosis and treatment.

Key words: coronary disease, gonadal steroid hormones； premenopause