Abstract: ［Abstract］ Objective〖HTSS〗〓To study the value of coronary artery corrected contrast medium concentration(CCO) in evaluating coronary stenosis, coronary plaque load and clinical prognosis in patients with coronary heart disease by spiral CT.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Two hundred and five patients with coronary artery disease with stenosis of left anterior descending artery were enrolled in this study. All of them had TIMI score and underwent coronary CT imaging with 256slice spiral CT. The CCO values in the anterior and posterior lumen of coronary artery stenosis and the CCO differences before and after the stenosis were measured by CT imaging workstation. Three acyl glycerol, total bilirubin, gamma glutamyl transferase, total cholesterol, high density lipoprotein cholesterol, uric acid, glycosylated hemoglobin, low density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B, apolipoprotein a, coronary arteriongraphy, homocysteine were detected in all patients. Patients underwent coronary angiography and intravascular ultrasound. Multivariate regression analysis was used to analyze the correlation between CCO difference, coronary arteriongraphy（CAG） coronary stenosis rate, intravenous ultrasound(IVUS) stenosis rate, plaque burden measured by IVUS and TIMI score.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The correlation coefficients between CCO difference, CAGmeasured coronary stenosis rate, IVUS stenosis rate, IVUSmeasured plaque load and TIMI score were 0.646, 0.464, 0.656 and 0.722 respectively. The determination coefficients of CAGmeasured coronary stenosis rate, IVUS stenosis rate, IVUSmeasured plaque load and TIMI score and CCO difference were 0.537 by multivariate linear regression analysis.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓CCO difference has a good correlation with coronary artery stenosis, plaque load and coronary artery intraluminal hemodynamics in patients with coronary heart disease. It may become a new rapid, noninvasive and convenient evaluation index of coronary heart disease.

Key words: coronary disease, coronary stenosis, plaque burden, prognosis