Abstract: Objective  To explore the clinical value of serum procalcitonin(PCT), albumin(ALB), and pancreatic stone protein(PSP) in diagnosing sepsis. 
Methods  A total of 322 children with sepsis were selected as the study subjects. According to the severity of the disease, the children were divided into the sepsis group(126 cases), the severe sepsis group(105 cases), and the septic shock group(91 cases). Another 80 healthy children were selected as the control group. Serum PCT, ALB and PSP levels were compared in each group to analyze the relevant influencing factors for the prognosis of children with sepsis, and the predictive value of PCT, ALB and PSP for the prognosis of children with sepsis was evaluated by ROC curve. 
Results  There were statistically significant differences in serum PCT, ALB and PSP levels among 4 groups(P＜0.05). PCT, PSP levels of sepsis group were higher than the control group, propagated level was lower than the control group. PCT, PSP levels of severe sepsis group were higher than that of sepsis group and the control group, propagated level below the sepsis group and the control group, PCT, PSP levels of septic shock group were higher than that of severe sepsis group, sepsis group and the control group, propagated levels below severe sepsis, sepsis group and the control group, the difference was statistically significant(P＜0.05). After 28 days of follow-up, 48 of the 322 children died(14.91%) and 274 survived(85.09%). The mortality of the severe sepsis group was higher than that of the sepsis group, and the mortality of the septic shock group was higher than that of the sepsis group and the severe sepsis group, and the difference was statistically significant(P＜0.01). PCT and PSP levels in the death group were higher than those in the survival group, ALB levels and PCIS scores were lower than those in the survival group, and the differences were statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that serum PCT, ALB, PSP and PCIS scores were risk factors for death in children with sepsis(P＜0.05). ROC curve showed that serum PCT, ALB and PSP had certain predictive value for the death of children with sepsis(area under the curve, Area under curve, AUC=0.741, 0.783, 0.784, P＜0.01), the sensitivity and specificity of the three combinations were 87.5% and 91.6%, with high predictive value(AUC=0.953, P＜0.01).
Conclusion  Serum PCT, ABL and PSP levels are of certain predictive value for the prognosis of children with sepsis, and the combined prediction of the three levels has high specificity and sensitivity, which makes the prediction of prognosis more accurate and clinical monitoring can be strengthened.

Key words: sepsis, procalcitonin, albumin, pancreatic stone protein