Abstract: Objective  To explore the relationship between airway inflammation and  phosphatidylinositol kinase 3/Protein Kinase B(PI3K/Akt) signaling pathway of activation eosinnophil(EOS) in patients with bronchial asthma. 
Methods  A total of 36 patients with bronchial asthma treated in our hospital were selected as observation group, and 36 people undergoing physical examination during the same period were selected as control group. The clinical data of the patients were collected, and the percentage of bronchial wall area to total airway cross-sectional area(WA%), the ratio of bronchial wall thickness to bronchial lumen diameter(T/D) and the distribution of cells in induced sputum were detected. The airway remodeling, inflammatory indicators, and PI3K/Akt signaling pathway-related protein levels in patients with different sputum eosinophil levels were analyzed, and Person correlation was used to analyze the relationship between inflammatory indicators and PI3K/Akt signaling pathway-related proteins. 
Results  The proportion of eosinophils in the observation group was significantly higher than that in the control group, while the proportion of neutrophils and macrophages in the observation group was significantly lower than that in the control group(P＜0.05). The fractional exhaled nitric oxide(FeNO) volume concentration, serum total IgE, T/D and WA in the high eosinophil group were significantly higher than those in the low eosinophil group(P＜0.05). The PI3K and p-Akt expression level of the patients in the high eosinophil group was significantly higher than that in the low eosinophil group(P＜0.05). Pearson analysis showed that FeNO volume concentration and serum total IgE were positively correlated with PI3K and p-Akt respectively(P＜0.05).  
Conclusion  The PI3K/Akt signaling pathway of EOS in patients with bronchial asthma is activated and has a positive correlation with airway inflammation(FeNO and serum IgE).

Key words: bronchial asthma, eosinophil, inflammation