Effect of butylphthalide injection on neurological function and serum inflammatory factor in patients with acute cerebral infarction

doi:10.3969/j.issn.10073205.2016.10.012

Abstract

Abstract: [
Abstract ] Objective ToinvestigatetheeffectofButylphthalideinjectiononneurologic
functionandseruminflammatoryfactorinpatientswithacutecerebralinfarction.Methods
Eightypatients withacutecerebralinfarctioninneurologydepartmentofourhospitalwere
enrolledandwererandomlydividedintocontrolgroup ( n =40 ) andtreatmentgroup ( n =40 ) .The
patientsinthecontrolgroupwereadministratedconventionaltherapy.Thepatientsintreatment
groupwereadministratedbutylphthalideinjection ( 100 mL , 2 /
day ) andconventionaltherapy.
Thecourseoftreatmentistwenty-onedaysincontrolgroupandtreatmentgroup.Thirtypatients
ofhealthyphysicalexaminationwereenrolledintonormalcontrolgroup.Thelevelsofserum
interleukin-6 ( IL-6 ), tumornecrosisfactor-α ( TNF-α ) weremeasuredbyenzyme-linkedabsorbed
assay.ThedegreeofeurologicaldeficitswasevaluatedbyNIHSS.Apollodocumentationlistwas
estimatedbymodifiedBarthelindex ( BI ) .Results Theclinicalcurativeeffectandeffectiverateof the2groupswerestatisticallysignificant ( P <0.05 ) .Aftertreatment , theNIHSSscoresofthe2
groupsweresignificantlydecreasedcomparedwiththosebeforetreatment.TheBIscoresofthe2
groupswassignificantlyhigherthanthatbeforetreatment.Thedifference wasstatistically
significant ( P <0.05 ) .ThelevelsofserumIL-6and TNF-αinpatientswithacutecerebral
infarctionweresignificantlyhigherthanthoseinthecontrolgroup ( P <0.05 ) .Theserumlevels
ofIL-6and TNF-α weresignificantlydecreasedinthe2groupsaftertreatmentthanbefore
treatment ( P <0.05 ) .Comparedwiththecontrolgroup , thelevelsofserumIL-6andTNF-αin
thetreatmentgroupweresignificantlydecreased ( P <0.05 ) .Conclusion Butylphthalideinjection
maydecreasethelevelsofserum IL-6 , TNF-α , inhibitinflammation , i

Key words: braininfarction , butylphthalide , inflammation

ZHANG Luqing1, CHEN Pin1, LI Ning1, DU Shupeng1, TIAN Huiyu2*. Effect of butylphthalide injection on neurological function and serum inflammatory factor in patients with acute cerebral infarction[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.10.012.

[1]	WANG Ling-ling, YANG Juan, WANG Tao, LI Jin-shi, SUI Hai-jing, ZHAO Xiao-hui. The mechanism of GV-971 improving cognitive impairment and reducing neuroinflammation in Alzheimer′s disease [J]. Journal of Hebei Medical University, 2023, 44(6): 629-634,639.
[2]	ZHANG Tong-yu, YANG Chuan-hui, XU Ning. Changes of inflammatory factors in diabetic peripheral neuropathy and their correlation with nerve conduction velocity [J]. Journal of Hebei Medical University, 2023, 44(5): 517-520,571.
[3]	JIANG Li-ping, LI Wen-zhen, WEI Jiang-mei. The expression of STC1, TWEAK, and miR-183 in COPD patients and their correlation [J]. Journal of Hebei Medical University, 2022, 43(6): 651-656,670.
[4]	LUO Zhi-zhong, FENG Kai, LUO Ya-qi. Study on the mechanism of protective effect of mannitou on cerebral ischemia-reperfusion in rats [J]. Journal of Hebei Medical University, 2022, 43(11): 1244-1249.
[5]	TENG Hua, LIU Miao-miao, ZHANG Rong-san, XIE Jian-hua, ZHANG Hong-zhen. Effect of systemic immune-inflammation index on prognosis of patients with small cell lung cancer [J]. Journal of Hebei Medical University, 2021, 42(8): 886-890.
[6]	LIU Hong-hong, XING Ning-ning, SHI Li-min, LI Ai-jun. Relationship between airway inflammation and PI3K/Akt signaling pathway activation of EOS in patients with bronchial asthma [J]. Journal of Hebei Medical University, 2021, 42(8): 881-885.
[7]	SUN Miao, ZHANG Xiao-ying, LI Yang-yang, HOU Li-hui, MENG Xiao-yu. Association of chronic low-grade inflammation with obesity and androgen with PCOS [J]. Journal of Hebei Medical University, 2021, 42(7): 823-826.
[8]	TIAN Shuo, ZHANG Ning, NIU Shu, LI Shen, SU Li, PING Fen. The protective effect of N-acetylcysteine against PM2.5-induced testicular toxicity [J]. Journal of Hebei Medical University, 2021, 42(7): 754-758,778.
[9]	LI Ying, LIU Miao-miao, HE Yan-lu-qi, ZHANG Hong-zhen. The prognostic value of pre-treatment systemic immune-inflammation index and fibrinogen in the prognosis of patients with non-small cell lung cancer [J]. Journal of Hebei Medical University, 2021, 42(5): 514-519.
[10]	LIU Xiu-ye, GUO Qiong-mei, WANG Xi-lian, ZHOU Chang-hao, WANG Li. Study on the effect of dexmedetomidine in the perioperative period of cesarean section in elderly parturients with gestational hypertension [J]. Journal of Hebei Medical University, 2021, 42(11): 1317-1322.
[11]	MENG Hai-yun, GU Xin-shun, ZHANG Qi. Relationship between the activity of butyrylcholinesterase and inflammatory factors, prognosis in patients with acute myocardial infarction [J]. Journal of Hebei Medical University, 2020, 41(8): 878-881,887.
[12]	QI Xiuyan1， LYU Yan1， DI Zhao2， ZHU Rongyan1， HOU Yongge1. Influence on carotid endometrium thickness and nerve function for the patients with acute cerebral infarction in old age by butylphthalide soft capsules combine with basic treatment#br# [J]. Journal of Hebei Medical University, 2018, 38(7): 757-759，791.
[13]	YIN Nan1， CHEN Hua2, DUAN Ruisheng1. Effect of fasudil hydrochloride combined with butylphthalide soft capsules on treatment of acute cerebral infarction and serum level of MMP2 and MMP9#br# [J]. Journal of Hebei Medical University, 2018, 38(12): 1376-1379.
[14]	XU Jin-xiu，GUO Ning-ning，ZHANG Yun-na，WANG Lin-xia. The correlated analysis of serum magnesium levels with type 2 diabetes mellitus complicated with acute cerebral infarction [J]. Journal of Hebei Medical University, 2016, 37(5): 520-522,527.
[15]	WANGLi-na1, WANGLi-juan 2,HUZhen-fang 3,LIUShi-yan1,LIU Yong-liang1, WANGPeng 1. Effectsofbutylphthalidecombinedwithedaravoneonblood-brainbarrierpermeability#br# andoccludinexpressionsincortexoffocalcerebralinfarctioninrats [J]. Journal of Hebei Medical University, 2016, 37(4): 385-388.

Effect of butylphthalide injection on neurological function and serum inflammatory factor in patients with acute cerebral infarction

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments