Journal of Hebei Medical University ›› 2021, Vol. 42 ›› Issue (10): 1189-1193,1209.doi: 10.3969/j.issn.1007-3205.2021.10.015

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Clinical observation of Adapalene gel-assisted supramolecular salicylic acid and human-like collagen dressing in the treatment of patients with mild to moderate acne

  

  1. Department of Dermatology, Xijing Hospital, the Frist Affiliated Hospital of PLA Air Force Military Medical Univertity, Xi′an 710000, China
  • Online:2021-10-25 Published:2021-10-28

Abstract: Objective To investigate the effect of adapalene gel-assisted supramolecular salicylic acid and human-like collagen dressings in the treatment of patients with mild to moderate acne and its influence on skin barrier function and the cosmetic satisfaction. 
Methods A total of 123 patients with mild to moderate acne admitted to our hospital were selected and divided into three groups according to the random number table method, with 41 cases in each group. The control group A was treated with supramolecular salicylic acid and human-like collagen dressing, the control group B was treated with adapalene gel, and the observation group was treated with adapalene gel-assisted supramolecular salicylic acid and human-like collagen dressing. The therapeutic effect, time of symptom improvement, skin lesions, and skin barrier function indexes[transepidermal water loss(TEWL), stratum corneum water content, pH value] before and after treatment, the cosmetic satisfaction and adverse reactions were compared among three groups. 
Results The total effective rate of the observation group was higher than that of control group A and control group B(P<0.05). There was no significant difference between control group A and control group B(P>0.05). The duration of erythema, pain, scab formation and complete shedding of scab in the observation group were shorter than those in control group A and control group B, and the above indicators in control group A were shorter than those in control group B(P<0.05). At 4 weeks after treatment, the number of papules, acne, abscess, nodules and cysts in the three groups was less than that before treatment, and the number was less in observation group than in the control group A and control group B, and less in the control group A than in the control group B(P<0.05). The TEWL, stratum corneum water content and pH value in the three groups were better than those before treatment, and the above indicators were better in the observation group than in control group A and control group B, and better in the control group A than in control group B(P<0.05). The cosmetic satisfaction of the observation group was higher than that of control group A and control group B(P<0.05), while there was no significant difference between control group A and control group B(P>0.05). There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05). 
Conclusion Adapalene gel-assisted supramolecular salicylic acid and human-like collagen dressings are effective in treating mild to moderate acne, with good patient satisfaction and safety. 


Key words: acne vulgaris, adapalene gel, supramolecular salicylic acid, human-like collagen dressings