Abstract: Objective To observe the effect of trazodone hydrochloride combined with noninvasive bi-level positive airway pressure(BiPAP) ventilation on serum peroxisome proliferator activated receptor-γ(PPAR-γ), chitinase-like protein(YKL-40) and von Willebrand factor(vWF) levels in patients with obstructive sleep apnea hypopnea syndrome(OSAHS). 
Methods In total, 162 patients with OSAHS were selected and randomly divided into the control group and the research group, with 81 cases in each group. The control group was given BiPAP ventilation treatment, and the research group was given trazodone hydrochloride combined with BiPAP ventilation treatment. Both groups were treated for 40 d. The efficacy, Pittsburgh sleep quality scale(PSQI) score, Calgary quality of life index(SAQLI) for OSAHS patients, apnea hypopnea index(AHI), lowest oxygen saturation(LSaO2), mean oxygen saturation(MSaO2) and serum PPAR-γ, YKL-40, vWF and the incidence of adverse reactions were compared between two groups. 
Results After treatment, the total effective rate of the research group was significantly better than that of the control group(P＜0.05). After treatment, the PSQI score of the research group was lower than that of the control group, while the SAQLI score was higher than that of the control group(P＜0.05). After treatment, AHI in the research group was lower than that in the control group, while LSaO2 and MSaO2 in the research group were higher than those in the control group(P＜0.05). After treatment, the serum PPAR-γ, YKL-40 and vWF in the research group were lower than those in the control group(P＜0.05). There was no difference in the total incidence of adverse reactions between two groups(P＞0.05). 
Conclusion Trazodone hydrochloride combined with BiPAP ventilation in the treatment of OSAHS patients can help ameliorate the symptoms, enhance the quality of life by improving the sleep quality of patients, and reduce the serum PPAR-γ, YKL-40and vWF levels.

Key words: sleep apnea, obstructive, trazodone hydrochloride, noninvasive bi-level positive airway pressure