Abstract: Objective To explore the effect of sufentanil combined with sevoflurane anesthesia on hemodynamics and postoperative agitation in pediatric adenoid hypertrophy resection. 
Methods A prospective study of 171 children undergoing adenoid hypertrophy resection was performed. According to the random number table method, they were divided into the observation group(n=86) and the control group(n=85). The observation group was given sufentanil combined with sevoflurane anesthesia, and the control group was given propofol combined with remifentanil anesthesia. The perioperative hemodynamics, postoperative agitation rate, facial expression scale(FPS) score, and observer's assessment of alertness/sedation(OAAS) score were compared between two groups. The incidence of adverse reactions was calculated. 
Results Pulse oxygen saturation（SpO2） and mean arterial pressure（MAP） in the two groups showed a trend of decreasing initially and then increasing, and heart rate（HR） showed a trend of increasing initially and then decreasing. The difference of interaction between groups, time points, and time points between groups was statistically significant with respect to fluctuation range of SpO2, MAP and HR(P＜0.05). The OAAS score of the two groups showed a trend of initial decreasing and then increasing, and the FPS score was increasing initially and then decreasing. The OAAS score of the observation group was higher than that of the control group, while the FPS score was lower than that of the control group. The difference in interaction between groups, time points, and time points between groups was statistically significant(P＜0.05). The agitation rates of the observation group at 6 h, 24 h and 48 h after operation were lower than those in the control group, and the differences were statistically significant(P＜0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant(P＜0.05). 
Conclusion Compared with propofol combined with remifentanil anesthesia, sufentanil combined with sevoflurane anesthesia for adenoid hypertrophy resection can stabilize hemodynamics, and reduce postoperative agitation rate, which is safer and more reliable. 

Key words: adenoid hypertrophy resection, sufentanil, sevoflurane