Abstract: ObjectiveTo study the relationship between serum glucagon-like peptide-1(GLP-1) and insulin-like growth factor 1 receptor(IGF-1R) in placental tissues and neonatal outcomes in patients with gestational diabetes. 
MethodsPregnant women undergoing pregnancy examination and women with full-term singleton pregnancy in our hospital were enrolled. They underwent 75 g OGTT examination at 24-28 weeks of pregnancy and were divided into GDM group and non-GDM group. Body mass index(BMI), age, gestational age, fasting plasma glucose(FPG), 1 h fasting plasma glucose after taking sugar(FPG1), 2 h fasting plasma glucose after taking sugar(FPG2), IGF-1R, glycosylated hemoglobin(HbA1c), and GLP-1 were compared between the two groups. Meanwhile, the relationship between GLP-1, IGF-1R and neonatal outcomes as well as the correlation between GLP-1 and IGF-1R was explored. 
ResultsThere were significant differences in BMI, FPG, FPG1, FPG2, IGF-1R, HbA1c, and serum GLP-1 between two groups before pregnancy(P＜0.05), but there was no difference in age and gestational age(P＞0.05). In the GDM group, 50 cases(25.0%) had adverse neonatal outcomes, and 10 cases(5%) in the non-GDM group had adverse neonatal outcomes, suggesting significant differences(χ2=31.373, P＜0.001). GLP-1 had a negative impact on adverse neonatal outcomes ［β=-0.141, OR=0.869(95%CI: 0.821-0.919)］, and IGF had a positive impact on adverse neonatal outcomes［β=0.745, OR= 2.107(95%CI: 1.214-3.656)］. The independent risk factors affecting adverse neonatal outcomes were GDM and IGF-1R. There was a negative correlation between GLP-1 and IGF-1R(r=-0.478, P＜0.05). 
ConclusionSerum GLP-1 in patients with gestational diabetes negatively affects adverse neonatal outcomes, while IGF-1R in placental tissues positively affects adverse neonatal outcomes, which warrants attention in clinical practice.

Key words: diabetes, gestational, glucagon, placenta