Abstract: Objective To explore the effect of orbicularis oculi muscle compound flap combined with correction of upper eyelid skin laxity in repairing large-area defect after surgery for eyelid xanthoma. 
Methods A total of 92 patients with large-area defect after surgery for eyelid xanthoma were selected and divided into observation group(n=46) and control group(n=46) according to the random number table method. The control group was surgically resected and sutured, and the observation group was treated with the orbicularis oculi muscle compound flap combined with correction of upper eyelid skin laxity. The duration of operation, granulation growth time, healing time, residual tumor score, depressed scar score, and score of pigment abnormalities, cosmetic effect, recurrence rate and complication rate were compared between two groups. 
Results There was no statistically significant difference in duration of operation between two groups(P＞0.05), and the granulation growth time and healing time of the observation group were shorter than those of the control group(P＜0.05). There was no significant difference in residual tumor score, depressed scar score, score of pigment abnormalities and comprehensive score in the two groups at one month after surgery(P＞0.05). At 6 months after operation, the residual tumor scores, depressed scar scores, score of pigment abnormalities and comprehensive scores of the two groups decreased(P＜0.05), which were lower in the observation group(P＜0.05). The excellent and good rates of observation group was 92.00%, which was higher than that(80.52%) in control group(P＜0.05). There was no statistically significant difference in the recurrence rate and complication rate between two groups(P＞0.05). 
Conclusion The orbicularis oculi muscle compound flap combined with correction of upper eyelid skin laxity can repair large-area defect of patients after surgery for eyelid xanthoma, which can shorten the recovery time, and improve the cosmetic effect, with good safety and reliability. 

Key words: eyelid neoplasms, orbicularis oculi muscle compound flap, correction of upper eyelid skin laxity