Abstract: Objective To investigate the risk factors of central serous chorioretinopathy (CSC), and to analyze the relationship between vascular endothelial growth factor (VEGF), high sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR) and CSC. 
Methods A total of 109 patients with CSC were selected (CSC group), and 103 volunteers undergoing physical examination during the same period were selected as the control group. General data, underlying diseases, past medical history and medication history were collected, VEGF, hs-CRP and ESR levels were detected, and the influencing factors of CSC were analyzed by multivariate Logistic regression. Receiver operating characteristic (ROC) curve was used to analyze the value of VEGF, hs-CRP and ESR in the diagnosis of CSC. 
Results The proportion of male gender, smoking history, drinking history, obstructive sleep apnea, hypothyroidism, combined nephropathy, helicobacter pylori infection, history of hormone use and day and night shift work were higher in CSC group than in control group (P＜0.05). The levels of VEGF, hs-CRP and ESR were higher in CSC group than in control group (P＜0.05). Male gender, day and night shift work, combined helicobacter pylori infection, hypothyroidism, VEGF, hs-CRP and ESR were risk factors for CSC (P＜0.05). The area under the receiver operating characteristic (ROC)curve of combined detection of VEGF, hs-CRP and ESR in the diagnosis of CSC was 0.886, which was higher than  that of VEGF, HS-CRP and ESR alone (0.722, 0.728 and 0.703) (P＜0.05). 
Conclusion Male gender, day and night shift work, helicobacter pylori infection, hypothyroidism and increased VEGF, hs-CRP and ESR are risk factors for CSC, and the combined detection of VEGF, hs-CRP and ESR has high effectiveness in the diagnosis of CSC.

Key words: central serous chorioretinopathy, vascular endothelial growth factor, high sensitivity C-reactive protein