Journal of Hebei Medical University ›› 2023, Vol. 44 ›› Issue (4): 386-391.doi: 10.3969/j.issn.1007-3205.2023.04.004

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Study on the expression and predictive value of AIM2, Lp-PLA2 and UCH-L1 in acute cerebral infarction

  

  1. 1.Department of Neurology, the First Hospital of Baoding City, Hebei Province, Baoding 071000, China; 
    2.Department of Oncology, Baoding Children′s Hospital, Hebei Province, Baoding 071052, China; 
    3.Department of Preventive Health Care,the First Hospital of Baoding City, 
    Hebei Province, Baoding 071000, China

  • Online:2023-04-20 Published:2023-04-20

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Abstract: Objective To investigate the relationship of the expression of absent in melanoma 2(AIM2) in peripheral blood mononuclear cells (PBMCs), the level of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) with severity of acute cerebral infarction(ACI) and prognosis of neurological impairment. 
Methods 150 ACI patients treated in Department of Neurology (ACI group)and 72 healthy volunteers undergoing physical examinations (control group) were selected.ACI group was divided into major infarction group (n=42), minor infarction group (n=61), and lacunar infarction group (n=47) according to the size of lesions. ACI group was divided into mild injury group (n=38), moderate injury group (n=59) and severe injury group (n=53) according to the National Institute of Stroke Rating Scale (NIHSS) score. ACI group was divided into good prognosis group (n=91) and poor prognosis group (n=59) according to modified RANKIN scale (MRS) score. The expression of AIM2 in PBMCs, and serum Lp-PLA2 and UCH-L1 levels were detected, to analyze the value of AIM2, Lp-PLA2 and UCH-L1 in predicting the prognosis of neurological impairment in patients with ACI. 
Results The expression of AIM2 in PBMCs and serum level of Lp-PLA2 and UCH-L1 in ACI group were higher than those in control group (P＜0.05), and higher in major infarction group than in small infarction group and lacunar infarction group(P＜0.05), in severe injury group than in moderate injury group and mild injury group(P＜0.05), and in poor prognosis group than in good prognosis group (P＜0.05). The area under the receiver operating characteristic (ROC)curve (AUC) of AIM2, Lp-PLA2 and UCH-L1 in predicting prognosis of neurological impairment in ACI patients was 0.864, which was higher than 0.695, 0.748 and 0.692 of AIM2, Lp-PLA2 and UCH-L1 alone (Z=3.922, 2.953 and 3.983, P＜0.05). 
Conclusion The expression of AIM2 in PBMCs and the levels of serum Lp-PLA2 and UCH-L1 of ACI patients are increased, which are related to the size of cerebral infarction, the degree of neurological defect and poor prognosis of neurological impairment. The combination of AIM2, Lp-PLA2 and UCH-L1 has a high value in the evaluation of prognosis of neurological impairment.  


Key words: cerebral infarction, neurological impairment, prognosis