Abstract: Objective To investigate the application of tirofiban combined with Solumbra technique for mechanical embolization in acute cerebral infarction caused by intracranial and extracranial large artery occlusion, and to analyze its effects on vascular recanalization rate, platelet function and prognosis. 
Methods A total of 120 patients with acute cerebral infarction caused by intracranial and extracranial large artery occlusion were selected, and they were grouped according to different medications used after intervention, with 60 patients in each group. Both groups underwent mechanical embolization by Solumbra technique, the control group was given aspirin combined with clopidogrel after embolization, and the observation group was given tirofiban after embolization. The clinical efficacy, vascular recanalization rate, cerebral blood flow ［meanblood flow velocity (Vm) of middle cerebral artery, peak systolic flow velocity (Vs), end-diastolic flow velocity (Vd)］, platelet function indexes ［mean platelet volume (MPV), platelet aggregation rate (PAgT), platelet adhesion rate (PAdT), platelet P-selectin］, neurological function ［National Institute of Health Stroke Scale (NIHSS)］ score, activities of daily living ［Barthel index (BI) score］, prognosis ［modified rankin scale (mRs) score］ and incidence of bleeding complications, and mortality were compared between two groups. 
Results The total effective rate and vascular recanalization rate of the observation group were higher than those of the control group (P＜0.05). The Vm, Vs, and Vd of the middle cerebral arteries in both groups increased with the duration of treatment, and the observation group showed a more significant increase; The difference between groups, time points, and time points between groups was statistically significant (P＜0.05). The levels of MPV, PAgT, PAdT, and P-selectin in the two groups decreased with the prolongation of treatment, and the observation group showed a more significant decrease. The difference between groups, time points, and time points between groups was statistically significant (P＜0.05). The NIHSS score and mRS score of the two groups decreased with the prolongation of treatment, and the observation group showed a more significant decrease. The Barthel index increased with the duration of treatment, and the observation group showed a more significant increase; The difference between groups, time points, and time points between groups was statistically significant (P＜0.05). There was no statistically significant difference in the incidence of bleeding complications and mortality rate between two groups at 90 d after treatment (P＞0.05). 
Conclusion The application of tirofiban combined with Solumbra technique for mechanical embolization in patients with acute cerebral infarction caused by intracranial and extracranial large artery occlusion is effective in improving platelet function and cerebral blood flow, increasing vascular recanalization rate, and promoting the recovery of neurological function, activities of daily living and prognosis, without increasing rate of bleeding complications and mortality rate.

Key words: cerebral infarction, Solumbra technique, tirofiban