Abstract: Objective To investigate the correlation of plasma omentin-1 with the degree of coronary heart disease (CHD). 
Methods A total of 114 patients who underwent coronary angiography during hospitalization and were diagnosed with CHD were enrolled, including 43 cases of unstable angina (UA), 27 cases of stable angina (SA), and 44 cases of acute myocardial infarction (AMI). Another 29 patients without stenosis by coronary angiography during the same time period were selected as the control group. The general data and laboratory tests of patients were compared, and plasma omentin-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). The coronary artery disease score (Gensini) was used to assess the degree of stenosis of coronary artery disease. Logistic regression was used to analyze the factors influencing the degree of stenosis of coronary artery lesions. Pearson correlation analysis was used to analyze the correlation between Gensini scores and plasma Omentin-1 levels. 
Results Compared with the control group, the proportion of males, age and smoking in the UA and AMI groups were higher, while HDL-C was lower; The proportion of hypertension in the SA, UA and AMI groups was higher, the proportion of diabetes and LDL-C in the AMI group was higher, while the LVEF and omentin-1 were lower, suggesting significant difference (P＜0.05).Compared with the SA group, the proportion of males and smoking history in the UA and AMI groups was higher, and the LDL-C was higher, while LVEF and omentin-1 were lower in the AMI group, suggesting significant difference (P＜0.05). Compared with the UA group, the proportion of males, LVEF, and omentin-1 in the AMI group was lower, while the proportion of diabetes history and LDL-C were higher in the AMI group, suggesting significant difference (P＜0.05). Compared with the mild stenosis group, the proportion of diabetes and LDL-C were higher, while LVEF was lower in severe stenosis group, and omentin-1 was lower in the moderate and severe stenosis groups, with significant difference (P＜0.05). Compared with the moderate stenosis group, patients with severe stenosis had higher LDL-C and lower omentin-1, suggesting significant difference (P＜0.05).The results of logistic regression analysis showed that sex, smoking history, diabetes history, LDL-C, LVEF, and plasma omentin-1 were risk factors for coronary artery stenosis in patients with CHD(P＜0.05). Pearson correlation analysis showed that plasma omentin-1 levels in the CHD group were negatively correlated with Gensini score (r=-0.766,  P＜0.05). 
Conclusion There is a negative correlation between plasma omentin-1 levels and degree of coronary artery disease, and high levels of plasma omentin-1 play a protective role in the pathogenesis of coronary artery disease. Therefore, plasma omentin-1 can be used for predicting the occurrence and progression of CHD, assessing the severity of coronary artery lesions, and becoming a potential biomarker for CHD progression. 

Key words: coronary disease, omentin-1, coronary artery lesion score