代谢综合征肾损害发病情况分析

doi:10.3969/j.issn.10073205.2017.02.006

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨代谢综合征肾损害发病情况的相关因素。
〖HTH〗方法〖HTSS〗〖KG*2〗选取常规肾功能检测的肥胖患者86例（失访1例），依据检测结果分为肾功能正常组（A组）31例，肾功能异常组（B组）54例；对全部入选患者进行治疗，并于12周后依据治疗效果将B组分为B1组31例（肾功能明显好转组）和B2组23例（肾功能未见好转组）。分别于患者体检时和治疗12周后复诊时检测各组患者的血脂、血流变学、肾功能、血压、空腹血糖（fasting blood glucose，FBG）及餐后2 h血糖（2hour postprandial glucose，2 hPBG）。
〖HTH〗结果〖HTSS〗〖KG*2〗体检时B组总胆固醇（total cholesterol，TC）、三酯甘油（triglyceride，TG）、FBG、2 hPBG、空腹胰岛素（fasting insulin，FINS）、胰岛素抵抗指数（homeostasis model assessmentinsulin resistance index，HOMAIR）水平明显高于A组，高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDLC）水平明显低于A组，差异均有统计学意义（P＜005），2组低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDLC）水平差异无统计学意义（P＞005）；24 h尿蛋白定量（24hour urinary protein excretion，24 hUP）、血尿素氮（blood urea nitrogen，BUN）及平均动脉压（mean arterial pressure，MAP）水平明显高于A组，肾小球滤过率（estimated glomerular filtration rate，eGFR）水平明显低于A组（P＜005）；B1组TC、TG、24 hUP、BUN、FBG、HOMAIR、MAP水平均低于B2组，eGFR水平明显高于B2组（P＜005）。治疗前A、B组血液流变学指标差异均无统计学意义（P＞005）；治疗后A、B 2组血液流变学指标明显低于治疗前，且B组血液流变学指标明显低于A组，差异均有统计学意义（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗HOMAIR及MAP的升高与代谢综合征肾损害的发病相关，可为疾病的预防和治疗指明新的研究方向。

关键词: 代谢综合征, 急性肾损伤, 血糖

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the related factors of metabolic syndrome associated nephropathy.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Eightysix obese patients （1 lost） for routine renal function detection in our hospital from March 2010 to March 2014 were selected, who were divided into two groups, 31 patients with normal renal function as group A, and 54 patients with renal injury as group B according to the testing results. All selected patients were treated, and the group B was divided into group B1(renal function were significantly improved,31 cases) and group B2(renal function did not improved,23 cases) according to the result of 12 weeks treatment. The lipids, blood rheology,renal function, blood pressure and glucose of the two groups were detected first came to medical examination and after 12 weeks treatment.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The total cholesterol(TC), triglyceride(TG), fasting blood glucose(FBG), 2hour postprandial glucose(2 hPBG), fasting insulin(FINS), and homeostasis model assessmentinsulin resistance index(HOMAIR) of group B were higher than that of the group A, high density lipoprotein cholesterol(HDLC) was significantly lower that that in group A, the difference was statistically significant(P＜005). The difference of low density lipoprotein cholesterol(LDLC) levels in 2 groups were not statistically significant(P＞005). 24hour urinary protein excretion(24 hUP), blood urea nitrogen(BUN) and mean arterial pressure(MAP) level were significantly higher than that in group A, eGFR level was significantly lower than that in group A(P＜005). The TC, TG, 24 hUP, BUN, FBG, HOMAIR and MAP of group B1 were lower than that in group A, the eGFR of group B1 was significantly higher than that in group B2, the difference was statistically significant(P＜005). Before treatment the blood rheology index of both A, B groups had no significant difference(P＞005); after the treatment the blood rheology index of both A, B groups were significantly lower than that before treatment, blood rheology index of B group were significantly lower than that in group A, the difference was statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓HOMAIR and MAP were important cause of the rise of metabolic syndrome associated nephropathy, and can be pointed out for the prevention and treatment of disease.

Key words: metabolic syndrome, acute kidney injury, blood glucose

郝玉杰，董燕飞，殷小文，王运红，张佩星. 代谢综合征肾损害发病情况分析[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2017.02.006.

HAO Yujie， DONG Yanfei， YIN Xiaowen， WANG Yunhong， ZHANG Peixing. Analysis of related factors of metabolic syndrome associated nephropathy[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2017.02.006.

[1]	尉全平, 杨建宝, 翟洪然, 侯凤香, 付晓康, 孙子梅. 孕妇糖代谢异常及维生素D缺乏对子代甲状腺功能的影响[J]. 河北医科大学学报, 2023, 44(5): 553-556,578.
[2]	张静, 孙立娟. 超极速脉搏波技术定量参数与代谢综合征患者血清Gal-3、IL-33水平的相关性分析 [J]. 河北医科大学学报, 2023, 44(5): 572-578.
[3]	廖苏丹, 张弛, 苏钢. 血清GLP-1、hs-CRP与2型糖尿病患者代谢综合征及认知功能的相关分析 [J]. 河北医科大学学报, 2023, 44(2): 157-160,183.
[4]	范素芳, 吕侯强. 血糖、炎症指标与COPD气流受限、治疗预后关联性及临床意义 [J]. 河北医科大学学报, 2023, 44(12): 1436-1441.
[5]	袁二伟, 朱雷, 许津莉, 郭华贤. 妊娠期糖尿病产妇脐血FTM、AGE水平与新生儿低血糖的相关性研究 [J]. 河北医科大学学报, 2023, 44(11): 1312-1316.
[6]	俞凯文, 孟令文. 应激性高血糖联合早期血乳酸清除率对重型颅脑外伤患者预后的临床意义 [J]. 河北医科大学学报, 2023, 44(1): 46-50.
[7]	邵婕, 杨美芳, 张秀. 妊娠期糖尿病患者血清GLP-1及胎盘组织中IGF-1R与新生儿结局的关系 [J]. 河北医科大学学报, 2022, 43(9): 1042-1046.
[8]	杜菲, 郑丽环, 王征, 房健健, 焦清海. miR-142-3p、miR-216a、miR-107-5p在ICU血液净化AKI患者中的表达及对疗效的评估价值分析 [J]. 河北医科大学学报, 2022, 43(8): 920-925.
[9]	韦琴, 史卫卫, 杨语嫣, 路笑颖, 曹亚景, 崔泽. 维生素D受体基因多态性与代谢综合征相关性的Meta分析[J]. 河北医科大学学报, 2022, 43(3): 280-285.
[10]	赵峻琪, 魏逸凡（综述）, 吴琪俊, 赵玉虹（审校）. 低碳水化合物饮食与代谢综合征发病关系的研究进展 [J]. 河北医科大学学报, 2022, 43(10): 1232-1236.
[11]	宋京花, 贾红艳, 邵天鹏, 柳志宝, 赵元平. 氢气对蛛网膜下腔出血致急性肾损伤大鼠的保护作用[J]. 河北医科大学学报, 2021, 42(6): 624-630.
[12]	韩晓凯, 韩晓华, 张建娥, 李涛, 薛涵月, 康建省. 腹腔镜减重与代谢手术治疗代谢综合征的效果分析[J]. 河北医科大学学报, 2021, 42(6): 676-679,685.
[13]	王婷婷（综述）, 李广平, 富华颖（审校）. 肺高血压与代谢综合征关系研究进展[J]. 河北医科大学学报, 2021, 42(4): 492-496.
[14]	于同芳, 郭永生, 王璠, 郭欣, 赵建宏, 池洪治. 无症状高尿酸血症患者血尿酸浓度分层与血脂、血糖的关系[J]. 河北医科大学学报, 2021, 42(3): 344-347,354.
[15]	李燕, 黄庆生, 方明星, 张丽霞, 郭建英, 王智勇. 黏附因子联合肾阻力指数对脓毒症相关性肾损伤的早期肾功能恢复的预测价值[J]. 河北医科大学学报, 2021, 42(12): 1387-1391,1396.

代谢综合征肾损害发病情况分析

Analysis of related factors of metabolic syndrome associated nephropathy

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价