CC类趋化因子22和叉头状翅膀样转录因子3在胆管癌组织中的表达及意义

doi:10.3969/j.issn.10073205.2018.01.005

河北医科大学学报

CC类趋化因子22和叉头状翅膀样转录因子3在胆管癌组织中的表达及意义

1.河北医科大学第二医院肝胆外科，河北石家庄 050000；2.河北医科大学第三医院肿瘤科，河北石家庄 050051

出版日期:2018-01-25 发布日期:2018-01-05
作者简介:王文斌（1973-），男，河北保定人，河北医科大学第二医院副主任医师，医学博士，从事肝胆外科疾病诊治研究。

Expression and significance of CCL22 and FOXP3 in cholangiocarcinoma

1.Department of hepatobiliary, the Second Hospital of Hebei Medical University, Shijiazhuang
050000, China；2.Department of Oncology, the Third Hospital of Hebei Medical University,
Shijiazhuang 050051, China

Online:2018-01-25 Published:2018-01-05

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨CC类趋化因22(CC class chemokines 22，CCL22)和叉头状翅膀样转录因子3（forkhead/winged helix transcription factor 3,FOXP3）在胆管癌组织中的表达及其临床意义。
〖HTH〗方法〖HTSS〗〖KG*2〗采用免疫组织化学法检测70例胆管癌组织和15例非肿瘤胆道上皮组织中CCL22、FOXP3的表达情况，分析其与胆管癌临床和预后的关系。
〖HTH〗结果〖HTSS〗〖KG*2〗70例胆管癌、15例非肿瘤胆道上皮组织中CCL22和FOXP3阳性表达率分别为62.4%（44/70）、20.0%（3/15）及71.4%（50/70）、13.3%（2/15）。CCL22和FOXP3蛋白在胆管癌组织中的表达水平均明显高于非肿瘤胆道上皮组织（P＜001）。有淋巴结转移者和TNM分期Ⅲ+Ⅳ期者较无淋巴结转移者和TNM分期Ⅰ+Ⅱ期者CCL22和FOXP3的表达阳性率高，差异有统计学意义（P＜005）。CCL22与FOXP3蛋白表达呈明显正相关（P＜001）。CCL22和FOXP3蛋白阴性表达者生存时间明显长于阳性表达者（P＜001）。
〖HTH〗结论〖HTSS〗〖KG*2〗CCL22和FOXP3可能对胆管癌发展及预后产生重要影响。

关键词: 胆管肿瘤, CC趋化因子22, 叉头状翅膀样转录因3

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the expression of CC class chemokines 22(CCL22) and the specific marker of regulatory T cells(Tregs) forkhead/winged helix transcription factor 3(FOXP3) and to analyze the correlation and the relationship with clinicopathological factors and prognosis in order to explore the effect of Tregs on tumor immunity in cholangiocarcinoma.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The expression of CCL22 and FOXP3 in 70 cases of cholangiocarcinoma and 15 cases of paracancer were detected by immunohistochemical staining.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive expression rates of CCL22 and FOXP3 in 70 cases of cholangiocarcinoma， 15 cases of nontumor bile duct epithelium were 62.4%, 20.0% and 71.4%, 13.3%, respectively. There was a significant difference among different groups(P＜001). The positive rates of CCL22 and FOXP3 were significantly higher in the stage Ⅲ+Ⅳ and lymph nodes metastasis patients than those in stage Ⅰ+Ⅱ and no lymph nodes metastasis patients（P＜005）. The expression of CCL22 was positively correlated with that of FOXP3(P＜0.01). Moreover survival time of negative expression in CCL22 and FOXP3 patients was longer than that of positive expression in CCL22 and FOXP3 patients（P＜001）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓CCL22 and FOXP3 may have great influence on development and prognosis of cholangiocarcinoma.

Key words: bile duct neoplasms, CC class chemokines 22, forkhead/winged helix transcription factor 3

王文斌1，刘〓兵2，吕海涛1，王天阳1，张腾飞1，何〓伟1. CC类趋化因子22和叉头状翅膀样转录因子3在胆管癌组织中的表达及意义[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.01.005.

WANG Wenbin1, LIU Bing2, LYU Haitao1, WANG Tianyang1, ZHANG Tengfei1, HE Wei1. Expression and significance of CCL22 and FOXP3 in cholangiocarcinoma[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.01.005.

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CC类趋化因子22和叉头状翅膀样转录因子3在胆管癌组织中的表达及意义

Expression and significance of CCL22 and FOXP3 in cholangiocarcinoma

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