关键词: 肌腱病, 羊膜, 模型, 动物

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the biomechanical characteristics of tendon healing and tendon adhesion after the freezedried amniotic membrane was used to reconstruct tendon sheath defect.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Forty healthy male leghorn chickens were used in this study. These animal models were randomly divided into two groups, the therapy group and the control group, with twenty chickens in each group. The model of tendon injury and tendon sheath defects was established in the third toes of chicken. After repairation of the flexor digitorum profundus tendon, a double freezedried amniotic membrane was used to reconstruct the tendon sheath defect of model in the therapy group, while the tendon sheath defect was not reconstructed in the control group. Five chickens were randomly selected from each group at the 1st, 2nd, 3rd and 4th week for biomechanical analysis. Biomechanical parameters, including the tensile strength of rupture  and the tensile adhesion strength of the rupture zone were measured at each time point.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓All experimental animals survived until the experiment was finished, and all incision healed well. The tensile strength of rupture decreased after the first two weeks, and increased gradually at the 3rd and 4th week. At the 1st, 2nd, 3rd and 4th week after the operation, the tensile strength of rupture in the therapy group was significantly higher than that in the control group(P＜005). The power consumption of the 2 groups was increased gradually at 1, 2, and 3,4 weeks. In the experimental group at 1, 2,3,4 weeks, the power consumption of the tendon adhesion zone was lower than that of the control group. The differences are statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Reconstruction of tendon sheath defects by freeze dried amniotic membrane can prevent tendon from exogenous healing, promote endogenous healing, and improve the quality of tendon healing, which provides a necessary condition for early active functional training.

Key words: tendinopathy, amnion； models, animal