特布他林联合阿奇霉素序贯治疗儿童肺炎支原体肺炎的临床研究

doi:10.3969/j.issn.10073205.2019.07.018

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨在阿奇霉素序贯治疗基础上，加用特布他林辅助治疗儿童肺炎支原体肺炎（mycoplasma pneumoniae pneumonia，MPP）的临床应用价值。
〖HTH〗方法〖HTSS〗〖KG*2〗选取MPP患儿116例，根据随机数字表法分为观察组和对照组各58例，2组均给予阿奇霉素序贯治疗，观察组在此基础上雾化给予硫酸特布他林，比较2组发热、咳嗽、喘憋、肺部啰音等症状体征消失时间，住院时间，临床疗效，不良反应，治疗前后肺泡灌洗液粒细胞-巨噬细胞集落刺激因子（granulocytemacrophage colony stimulating factor，GMCSF）、血清CXC趋化因子配体8（CXC chemokine ligand 8，CXCL8）及相关炎症因子水平。
〖HTH〗结果〖HTSS〗〖KG*2〗观察组发热、咳嗽、肺部啰音、喘憋消失时间，住院时间均短于对照组，差异有统计学意义（P＜005）。观察组临床疗效优于对照组，总有效率高于对照组，差异有统计学意义（P＜005）。治疗后，2组GMCSF、CXCL8、白细胞介素6（interleukin6，IL6）、肿瘤坏死因子α（tumor necrosis factorα，TNFα）、C反应蛋白（Creactive protein，CRP）水平均低于治疗前，且观察组GMCSF、CXCL8、IL6、TNFα、CRP水平均低于对照组，差异有统计学意义（P＜005）。2组不良反应发生率差异无统计学意义（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗特布他林辅助阿奇霉素序贯疗法治疗儿童MPP，具有协同作用，可以抑制炎症反应，降低GMCSF、CXCL8及相关炎症因子的表达水平，改善支气管狭窄，降低气道高反应性，缓解临床症状，缩短治疗时间，值得临床推广应用。

关键词: 肺炎, 支原体, 阿奇霉素, 特布他林

Abstract: ［Abstract］〓Objective〖HTSS〗〓To observe the clinical effect of terbutaline combined with azithromycin in the treatment of mycoplasma pneumoniae pneumonia(MPP).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 116 cases of children with MPP were selected as the research object in our hospital. The patients were randomly divided into observation group and control group with 58 cases in each group. Patients in both groups were given azithromycin sequential therapy, and patients in the observation group were given terbutaline sulfate as well. The extinction time of symptoms and signs, the length of hospital stay, the clinical curative effect, the adverse reactions and the levels of interleukin6(IL6), tumor necrosis factorα(TNFα), Creactive protein(CRP), granulocytemacrophage colony stimulating factor(GMCSF) and CXC chemokine ligand 8(CXCL8) were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The extinction time of symptoms and signs and the time of hospitalization of the observation group were significantly shorter than that of the control group, and the difference was statistically significant(P＜005). The clinical efficacy of the observation group was better than that of the control group, and the total effective rate was higher than that of the control group(P＜005). After treatment, the levels of GMCSF, CXCL8, IL6, TNFa and CRP in the two groups were lower than those before treatment, and the levels of GMCSF, CXCL8, IL6, TNFα and CRP in the observation group were lower than those of the control group(P＜005). There was no significant difference in the incidence of adverse reactions between the two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Terbutaline combined with Azithromycin sequential therapy in the treatment of MPP in children has synergistic effect. It can inhibit inflammation, reduce the expression levels of GMCSF, CXCL8 and related inflammatory factors, improve bronchial stenosis, reduce airway hyperresponsiveness, alleviate clinical symptoms and shorten treatment time. It is worthy of clinical application.

Key words: pneumonia, mycoplasma； azithromycin, terbutaline

王志坤，王建忠，李〓彤，韩金林. 特布他林联合阿奇霉素序贯治疗儿童肺炎支原体肺炎的临床研究[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2019.07.018.

WANG Zhikun， WANG Jianzhong， LI Tong， HAN Jinlin. Clinical effect of terbutaline combined with azithromycin in the treatment of mycoplasma pneumoniae pneumonia[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2019.07.018.

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特布他林联合阿奇霉素序贯治疗儿童肺炎支原体肺炎的临床研究

Clinical effect of terbutaline combined with azithromycin in the treatment of mycoplasma pneumoniae pneumonia

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