河北医科大学学报 ›› 2025, Vol. 46 ›› Issue (1): 49-54.doi: 10.3969/j.issn.1007-3205.2025.01.009

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儿童甲型、乙型流行性感冒临床特征及外周血早期预警指标

  

  1. 天津市儿童医院,天津大学儿童医院感染科，天津市儿童出生缺陷防治重点实验室，天津 300134

  • 出版日期:2025-01-25 发布日期:2025-01-22
  • 作者简介:张雯（1986-），女，河北武强人，天津市儿童医院主治医师，医学硕士，从事儿内科疾病诊治研究。
  • 基金资助:
    天津市卫生健康科技项目（TJWJ2021QN049）；天津市医学重点学科（专科）建设项目资助（TJYXZDXK-040A）

Clinical characteristics and early warning indicators of influenza A and influenza B in children

  1. Department of Infectious Diseases, Tianjin Children′s Hospital, Children′s Hospital of Tianjin 
    University, Tianjin Key Laboratory of Birth Defects for Prevention and 
    Treatment, Tianjin 300134, China

  • Online:2025-01-25 Published:2025-01-22

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摘要： 目的 分析儿童甲型、乙型流行性感冒（简称流感）的临床特征及外周血特点，尤其是中性粒细胞、淋巴细胞比值的意义，以期提高对儿童流感的认识水平，为儿童流感的早期诊断提供参考依据。
方法 选取发热和（或）上呼吸道感染症状的患儿428例，根据流感病毒抗原结果分为甲型流感病毒阳性（甲流组）172例、乙型流感病毒阳性（乙流组）132例及对照组124例，回顾性总结分析其流行病学特征、临床表现、外周血常规检查结果。
结果 3组间外周血白细胞水平比较差异无统计学意义(P＞0.05)；甲流组和乙流组的外周血中性粒细胞、淋巴细胞、中性粒细胞与淋巴细胞比值（neutrophil-to-lymphocyte ratio,NLR）及C反应蛋白（C-reactive protein，CRP）水平分别与对照组比较，差异有统计学意义(P＜0.05)。但在甲流组和乙流组中性粒细胞、淋巴细胞、NLR、CRP比较差异无统计学意义(P＞0.05)。
结论 外周血常规中性粒细胞比例、淋巴细胞比例、CRP及NLR可为流感患儿早期诊断提供参考依据。


关键词: 流感, 人, 疾病特征, 儿童

Abstract: Objective To analyze the clinical characteristics and peripheral blood characteristics of influenza A and B (hereinafter referred to as influenza)in children, especially the significance of neutrop hil-to-lymphocyte ratio (NLR), in order to improve the understanding level of influenza in children and provide reference for early diagnosis of influenza in children. 
Methods A total of 428 children with fever and/or upper respiratory tract infection were selected. According to the results of influenza virus antigen, they were divided into influenza A virus (IAV) positive group (IAV group, n=172), influenza B virus (IBV) positive group (IBV group, n=132) and control group (n=124).The epidemiological characteristics, clinical manifestations and routine examination results of peripheral blood were reviewed and analyzed. 
Results There were no significant differences in while blood cell (WBC) levels among the three groups (P＞0.05). The levels of neutrophils, lymphocytes， NLR and C-reactive protein(CRP) in peripheral blood of IAV group and IBV group were significantly different from those of control group, respectively (P＜0.05). However, there was no significant difference in neutrophils, lymphocytes, NLR, and CRP between IAV group and IBV group (P＞0.05). 
Conclusion The proportion of neutrophils, lymphocytes， CRP and NLR in peripheral blood routine can provide reference for early diagnosis of influenza in children. 


Key words: influenza, human, disease characteristics, child

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