子痫前期患者游离脂肪酸、胎盘生长因子水平与无创血流动力学监测结果的相关性

doi:10.3969/j.issn.1007-3205.2025.01.015

摘要/Abstract

摘要： 目的探究子痫前期患者游离脂肪酸（free fatty acids,FFA）、胎盘生长因子（placental growth factor,PLGF）与无创血流动力学监测结果的相关性，提高对子痫前期患者的早期诊断和管理。
方法选择子痫前期患者80例作为观察组，同期进行孕检的正常孕妇75例作为对照组，比较2组FFA、PLGF和血流动力学指标，分析观察组患者FFA、PLGF水平与血流动力学指标的相关性。
结果观察组血清PLGF水平低于对照组［（62.03±18.45）ng/L vs.（106.95±12.34）ng/L］，FFA水平高于对照组［（0.77±0.66）mmol/L vs. 0.59±0.57）mmol/L］（P＜0.05）。观察组平均动脉压（mean arterial pressure,MAP）［观察组vs.对照组：（103.56±11.12）mmHg vs. （84.87±9.54）mmHg］、全身血管阻力（systemic vascular resistance,SVR）［（1 467.45±487.12）dyne·s·cm5 vs. （1 032.45±274.45） dyne·s·cm5］、全身血管阻力指数（systemic vascular resistance index,SVRI）［（2 596.58±790.69）dyne·s·cm5·m2 vs. （1 762.45±537.42） dyne·s·cm5·m2］、组织灌注量（tissue perfusion,TFC）［（33.22±5.23）koh-m-1 vs. （30.45±5.87）koh-m-1］水平高于对照组（P＜0.05），心脏指数（cardiac index,CI）［（3.12±0.56）L·min-1·（m2）-1 vs. （3.45±0.71）L·min-1·（m2）-1］、心输出量（cardiac output,CO）［（5.54±1.13）L/min vs.（6.23±1.15）L/min］、卒中指数（stroke index,SI）［（34.36±7.74）mL/搏·m2 vs.（39.12±8.24）mL/搏·m2］、卒中容量（stroke volume,SV）［（62.35±14.54）mL/搏vs.（69.22±15.11）mL/搏］、动脉顺应性指数（arterial compliance index,ACI）［（91.87±34.89）10-2·s-2 vs.（117.12±42.78）10-2·s-2］、血管指数（vascular index,VI）［（51.45±18.87）10-3·s-1 vs. （67.14±20.53）10-3·s-1］低于对照组（P＜0.05），2组左心作功指数、收缩时间比率变化差异无统计学意义（P＞0.05）。经Spearman相关性分析，FFA水平与子痫前期严重程度呈正相关（r=0.615，P＜0.05），PLGF水平与子痫前期严重程度呈负相关（r=-0.587，P＜0.05）。观察组患者的MAP、SVR、SVRI、TFC与FFA水平呈正相关，与PLGF水平呈负相关；CI、CO、SI、SV、ACI、VI与PLGF水平呈正相关，与FFA水平呈负相关。
结论子痫前期患者FFA水平升高，PLGF水平降低，FFA和PLGF水平与无创血流动力学监测结果间具有一定的相关性，对子痫前期病情的早期诊断具有辅助作用。

关键词: 子痫, 脂肪酸类, 胎盘生长因子

Abstract: Objective To explore the correlation between free fatty acids (FFA), placental growth factor (PLGF), and results of non-invasive hemodynamic monitoring in patients with preeclampsia to enhance the early diagnosis and management of preeclampsia.
Methods Eighty patients with preeclampsia were selected as the observation group, and 75 normal pregnant women undergoing prenatal examinations during the same period were selected as the control group. The levels of FFA, PLGF, and hemodynamic indicators were compared between the two groups, and the correlation between FFA, PLGF levels, and hemodynamic indicators in the observation group was analyzed.
Results The serum PLGF levels in the observation group were lower than those in the control group ［(62.03±18.45) ng/L vs. (106.95±12.34) ng/L］, while the FFA levels were higher than those in the control group ［(0.77±0.66) mmol/L vs. (0.59±0.57) mmol/L］ (P＜0.05). The mean arterial pressure (MAP) in the observation group was higher than that in the control group ［(103.56±11.12) mmHg vs. (84.87±9.54) mmHg］, as were the systemic vascular resistance (SVR) ［(1,467.45±487.12) dyne·s·cm5 vs. (1 032.45±274.45) dyne·s·cm5］, systemic vascular resistance index (SVRI) ［(2 596.58±790.69) dyne·s·cm5·m2 vs. (1 762.45±537.42) dyne·s·cm5·m2］, and tissue perfusion ［(33.22±5.23) koh-m-1 vs. (30.45±5.87) koh-m-1］ levels (P＜0.05). The cardiac index (CI) ［(3.12±0.56) L·min-1·（m2）-1 vs. (3.45±0.71) L·min-1·（m2）-1］, cardiac output (CO) ［(5.54±1.13) L/min vs. (6.23±1.15) L/min］, stroke index (SI) ［(34.36±7.74) mL/beat·m2 vs. (39.12±8.24) mL/beat·m2］, stroke volume (SV) ［(62.35±14.54) mL/beat vs. (69.22±15.11) mL/beat］, arterial compliance index (ACI) ［（91.87±34.89）10-2·s-2 vs.（117.12±42.78）10-2·s-2］, and vascular index (VI) ［（51.45±18.87）10-3·s-1 vs.（67.14±20.53）10-3·s-1］ levels in the observation group were lower than those in the control group (P＜0.05). There were no significant differences in the changes in the left ventricular function index and systolic time ratio between the two groups (P＞0.05). Spearman correlation analysis showed that FFA levels were positively correlated with the severity of preeclampsia (r=0.615, P＜0.05), while PLGF levels were negatively correlated with the severity of preeclampsia (r=-0.587, P＜0.05). In the observation group, MAP, SVR, SVRI, and tissue perfusion were positively correlated with FFA levels and negatively correlated with PLGF levels. Conversely, CI, CO, SI, SV, ACI, and VI were positively correlated with PLGF levels and negatively correlated with FFA levels.
Conclusion In patients with preeclampsia, FFA levels are elevated, and PLGF levels are decreased. There is a certain correlation between the levels of FFA and PLGF and the results of non-invasive hemodynamic monitoring, which can aid in the early diagnosis of preeclampsia.

Key words: eclampsia, fatty acids, placenta growth factor

孙甜, 于立涛. 子痫前期患者游离脂肪酸、胎盘生长因子水平与无创血流动力学监测结果的相关性 [J]. 河北医科大学学报, 2025, 46(1): 86-91.

SUN Tian, YU Li-tao. Correlation of free fatty acid and placental growth factor levels with the results of non-invasive hemodynamic monitoring in preeclamptic patients [J]. Journal of Hebei Medical University, 2025, 46(1): 86-91.

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子痫前期患者游离脂肪酸、胎盘生长因子水平与无创血流动力学监测结果的相关性

Correlation of free fatty acid and placental growth factor levels with the results of non-invasive hemodynamic monitoring in preeclamptic patients

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