河北医科大学学报 ›› 2025, Vol. 46 ›› Issue (2): 208-213,封三.doi: 10.3969/j.issn.1007-3205.2025.02.014

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CGF纤维蛋白液联合Bio-Oss骨粉在颌骨缺损修复中的应用价值

  

  1. 安徽省马鞍山十七冶医院口腔科，安徽 马鞍山 243000

  • 出版日期:2025-02-25 发布日期:2025-02-27
  • 作者简介:路沈晨（1987-），男，安徽马鞍山人，安徽省马鞍山十七冶医院主治医师，医学硕士，从事口腔科疾病诊治研究。
  • 基金资助:
    安徽省高校自然科学研究项目(ZR2019B02)

The application value of CGF fibrin solution combined with Bio-Oss bone powder in the repair of jawbone defects

  1. Department of Stomatology, the 17th Metallurgical Hospital, Anhui Province, Ma′anshan, 243000, China

  • Online:2025-02-25 Published:2025-02-27

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摘要： 目的 探讨富自体浓缩生长因子（concentrated growth factors，CGF）纤维蛋白液联合Bio-Oss骨粉在颌骨缺损修复中的应用价值。
方法 选取安徽省马鞍山十七冶医院收治的颌骨囊肿术后骨缺损患者80例，按随机数字表法分为观察组与对照组，每组40例。对照组给予Bio-Oss骨粉治疗，观察组在对照组基础上联合CGF纤维蛋白液治疗。比较2组切口愈合情况，检测其骨缺损填充区域电子计算机断层扫描仪（Computed Tomography，CT）值，比较2组骨吸收量、骨密度、颌骨高度及宽度、并发症发生情况。
结果 观察组切口愈合情况优于对照组（P＜0.05）；2组骨缺损填充区域CT值均呈先升高再降低趋势，术后1个月达峰值，观察组骨缺损填充区域CT值大于对照组，组间、时点间、组间·时点间交互作用差异有统计学意义（P＜0.05）；术后6个月，2组骨吸收量及骨密度高于术后3个月,上颌骨高度、下颌骨高度及宽度高于术后3个月（P＜0.05），术后3个月、术后6个月,观察组骨吸收量及骨密度低于对照组,上颌骨高度、下颌骨高度及宽度高于对照组（P＜0.05）；观察组总并发症发生率低于对照组（P＜0.05）。
结论 颌骨囊肿术后颌骨缺损患者采用CGF纤维蛋白液联合Bio-Oss骨粉治疗不仅能促进骨修复、骨愈合以及颌骨外形恢复，还能减少其骨吸收，提高骨密度，具有安全性。


关键词: 颌骨囊肿, 富自体浓缩生长因子, 海奥骨粉

Abstract: Objective To explore the application value of concentrated growth factor (CGF) fibrin solution combined with Bio-Oss bone powder in the repair of jawbone defects. 
Methods Eighty patients with jawbone defects after jaw cyst surgery in the 17th Metallurgical Hospital were selected and divided into an observation group (n=40) and a control group (n=40) using a random number table method. The control group was treated with Bio-Oss bone powder, while the observation group was supplemented with CGF fibrin solution on the basis of the control group. The healing of incisions in the two groups was compared, the computed tomography (CT) values of the bone defect filling area were measured, and the bone resorption, bone density, jawbone height and width, and incidence of complications between the two groups were detected. 
Results The observation group showed better wound healing than the control group (P＜0.05). The CT values of the bone defect filling areas in both groups showed a trend of first increasing and then decreasing, reaching a peak at one month after surgery. The CT values of the bone defect filling areas in the observation group were higher than those in the control group, and there were significant differences in the interaction between groups, time points, and time points between groups (P＜0.05). At 6 months after surgery, the bone resorption and bone density of both groups were higher than those at 3 months after surgery, and the height of the maxilla as well as the height and width of the mandible was higher than that at 3 months after surgery (P＜0.05). At 3 months and 6 months after surgery, the bone resorption and bone density of the observation group were lower than those of the control group, while the height of the maxilla as well as the height and width of the mandible was higher than that of the control group (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group (P＜0.05). 
Conclusion The use of CGF fibrin solution combined with Bio-Oss bone powder for the treatment of patients with jawbone defects after after jawcyst surgery can not only promote bone repair, bone healing, and jawbone shape recovery, but also reduce bone resorption, and improve bone density, with good safety. 


Key words: jawcyst, concentrated growth factor, Bio-Oss bone powder

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