河北医科大学学报 ›› 2025, Vol. 46 ›› Issue (7): 785-791.doi: 10.3969/j.issn.1007-3205.2025.07.007

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血清VEGFR-2、sVEGFR-1、IGFBP-3在原发性喉癌患者中的表达水平及临床意义

  

  1. 1.河北省邯郸市眼科医院耳鼻咽喉科，河北 邯郸 056000；2.河北医科大学第四医院耳鼻咽喉头颈外科，
    河北 石家庄 050011；3.河北省保定市第四中心医院耳鼻喉科，河北 保定 072350

  • 出版日期:2025-07-25 发布日期:2025-07-24
  • 作者简介:程洪坤（1976-），男，河北临漳人，河北省邯郸市眼科医院副主任医师，医学学士，从事耳鼻咽喉科疾病诊治研究。

  • 基金资助:
    河北省重点研发计划项目（20377709D）

Expression and clinical significance of serum VEGFR-2, sVEGFR-1, and IGFBP-3 levels in patients with primary laryngeal cancer

  1. 1.Department of Otolaryngology, Handan Eye Hospital, Hebei Province, Handan 056000, China; 
    2.Department of Otolaryngology Head and Neck Surgery, the Fourth Hospital of 
    Hebei Medical University, Shijiazhuang 050011, China; 3.Department of 
    Otolaryngology, the Fourth Central Hospital, Hebei Province, 
    Baoding 072350, China

  • Online:2025-07-25 Published:2025-07-24

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摘要： 目的 旨在探讨血清血管内皮生长因子受体2 (vascular endothelial growth factor receptor-2，VEGFR-2)、可溶性血管内皮细胞生长因子受体1(soluble vascular endothelial growth factor receptor-1,sVEGFR-1)、胰岛素样生长因子结合蛋白3（insulin-like growth factor binding protein-3，IGFBP-3)水平作为原发性喉癌（primary laryngeal cancer，PLC）的生物标志物的意义。
方法 选取2019年7月—2020年12月在河北省邯郸眼科医院和河北医科大学第四医院住院治疗的PLC患者67例（考虑随访生存期3年）为观察组，另选取同期健康体检者25例作为对照组。抽取患者清晨空腹血液，检测血清VEGFR-2、sVEGFR-1、IGFBP-3水平，并分析其对于PLC患者的临床意义。
结果 观察组血清VEGFR-2［（10 697±1 687）ng/L ］、sVEGFR-1［（95.42±13.87）ng/L］、IGFBP-3［（19 415±1 184）ng/L ］水平明显高于对照组［（8 619±1 721）ng/L、（78.95±15.13）ng/L、（9 547±1 036）ng/L］，差异有统计学意义（t=5.227、4.943、36.728，P＜0.001）。随访时间为3年，按照VEGFR-2的截断值分为＞8 785 ng/L（高表达，n=50）和≤8 785 ng/L（低表达，n=17），低表达VEGFR-2患者生存率差，差异有统计学意义（χ2=6.735，P=0.009）。按照sVEGFR-1的截断值分为＞84 ng/L（高表达，n=47）和≤84 ng/L（低表达，n=20），高表达sVEGFR-1患者生存率较差，差异有统计学意义（χ2=3.760，P=0.042）。按照IGFBP-3的截断值分为＞14 815 ng/L（高表达，n=53）和≤14 815 ng/L（低表达，n=14），高表达和低表达IGFBP-3患者的生存率差异无统计学意义（χ2=1.940，P=0.164）。
结论 与正常人群相比，PLC患者血清VEGFR-2、sVEGFR-1、IGFBP-3水平显著升高，血清sVEGFR-1高水平以及VEGFR-2低水平的PLC患者预后生存率较差。


关键词: 喉肿瘤, 血管内皮生长因子受体2, 胰岛素样生长因子结合蛋白质3

Abstract: Objective To investigate the significance of serum vascular endothelial growth factor receptor-2 (VEGFR-2), soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels as biomarkers for primary laryngeal cancer (PLC). 
Methods A total of 67 patients with PLC who were hospitalized at Handan Eye Hospital and the Fourth Hospital of Hebei Medical University from July 2019 to December 2020 (considering a follow-up survival period of 3 years) were selected as the observation group, and 25 healthy individuals who underwent physical examinations during the same period were selected as the control group. Fasting blood samples were collected from patients in the morning, and serum levels of VEGFR-2, sVEGFR-1, and IGFBP-3 were measured to analyze their clinical significance for PLC patients. 
Results The levels of serum VEGFR-2 ［(10 697±1 687) ng/L］, sVEGFR-1 ［(95.42±13.87) ng/L］, and IGFBP-3 ［(19 415±1 184) ng/L］ in the observation group were significantly higher than those in the control group ［(8 619±1 721) ng/L, (78.95±15.13) ng/L, (9 547±1 036) ng/L］, and the differences were statistically significant (t=5.227, 4.943, 36.728, P＜0.001). The follow-up period was 3 years, and according to the cutoff value of VEGFR-2, patients were divided into those with ＞8 785 ng/L (high expression, n=50) and those with ≤8 785 ng/L (low expression, n=17). Patients with low expression of VEGFR-2 had poor survival rates, and the difference was significant (χ2=6.735, P=0.009). According to the cutoff value of sVEGFR-1, patients were divided into those with ＞84 ng/L (high expression, n=47) and those with ≤84 ng/L (low expression, n=20). The survival rate of patients with high expression of sVEGFR-1 was poor, and the difference was significant (χ2=3.760, P=0.042). According to the cutoff value of IGFBP-3, patients with IGFBP-3 were divided into those with ＞14 815 ng/L (high expression, n=53) and those with ≤14 815 ng/L (low expression, n=14). There was no significant difference in survival rate between patients with high and low IGFBP-3 expression (χ2=1.940, P=0.164). 
Conclusion Compared with the normal population, PLC patients have significantly increased levels of serum VEGFR-2, sVEGFR-1, and IGFBP-3. PLC patients with high levels of serum sVEGFR-1 and low levels of VEGFR-2 have a poorer prognosis and survival rate. 


Key words: laryngeal neoplasms, vascular endothelial growth factor receptor-2, insulin-like growth factor binding protein 3

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