河北医科大学学报

• 论著 • 上一篇    下一篇

原发性甲状旁腺功能亢进症 21 例临床分析

  

  1. 1.河北医科大学第二医院甲状腺外科,河北 石家庄 050000;2.河北医科大学第二医院泌尿外科, 河北 石家庄 050000
  • 出版日期:2016-04-25 发布日期:2016-05-18
  • 作者简介:冀宏( 1981- ),女,河北枣强人,河北医科大学第二 医院主治医师,医学硕士,从事甲状腺、乳腺外科疾病诊治研究。

Clinical analysis with 21 cases of primary hyperparathyroidism

  1. 1.Department of Thyroid Surgery, the Second Hospital of Hebei Medical University,
    Shijiazhuang 050000, China;2.Department of Urology, the Second Hospital of Hebei
    Medical University, Shijiazhuang 050000, China
  • Online:2016-04-25 Published:2016-05-18

摘要: [摘要] 目的 探讨原发性甲状旁腺功能亢进症( primaryhyperparathyroidism , PHPT )的临床表现、诊断方
法、早期监测措施及误诊原因,提高对甲状旁腺疾病的认识。方法 收集 21 例 PHPT 患者的临床资料,并对其临床
特征进行分析。结果 21 例 PHPT 患者病理回报均为甲状旁腺腺瘤,临床表现包括骨痛、骨质疏松、病理性骨折、
泌尿系结石等。术 前 19 例 ( 90.1% )患 者 全 段 甲 状 旁 腺 激 素 水 平 升 高, 18 例 ( 85.7% )患 者 血 钙 升 高, 13 例
(
61.9% )患者血磷降低, 11 例( 52.4% )患者血碱性磷酸酶升高。应用颈部彩色超声的病灶检出率为 81.0% ( 17 /
21 ),颈部 CT 病灶检出率为 53.3% ( 8 / 15 ),甲状旁腺核素显影病灶检出率为 100.0% ( 21 / 21 )。颈部超声联合血钙
检查病灶检出率可达 95.2% ( 20 / 21 )。所有病例均行患侧甲状旁腺切除术,术后 21 例均出现口周、四肢麻木,出现
四肢抽搐 5 例( 23.9% )。结论 临床医生应提高对甲状旁腺疾病的认识,采用颈部彩色超声联合血钙检查有助于
疾病的筛查,手术是治疗该疾病的唯一手段,术前准确的定位有利于缩小术中探查范围,减少周围组织损伤。

关键词: 甲状旁腺功能亢进症, 甲状旁腺肿瘤, 诊断, 治疗

Abstract: [
Abstract ] Objective Toinvestigateclinicalmanifestations , diagnosis methodandearly
detectionmeasuresand misdiagnosisreasonsofprimaryhyperparathyroidism ( PHPT ) andto
raiseawarenessofparathyroiddisease.Methods Theclinicaldataof21casesofpatientswith
PHPTwerecollectedandtheirclinicalfeatureswereanalyzed.Results Atotalof21PHPT
patientswerepathologicallydiagnosedwithparathyroidadenoma.Theirclinicalmanifestations
includedbonepain , osteoporosis , pathologicfractures , urinarycalculiandsoon.Beforesurgery ,
elevatedintactparathyroidhormonelevels werefoundin19cases ( 90.1% ), elevatedblood
calcium werefoundin18cases ( 85.7% ), reducedbloodphosphorus wasfoundin13cases
(
61.9% ) andelevatedbloodalkalinephosphatasewerefoundin11cases ( 52.4% ) .Thelesion
detectionratewas81.0% ( 17 / 21 ) byneckcolorDopplerultrasound.Thelesiondetectionratewas
53.3% ( 8 / 15 ) byneck CT.Thelesiondetectionrate was100.0% ( 21 / 21 ) byparathyroid
radionuclideimagingand95.2% ( 20 / 21 ) by neck ultrasoundcombined with bloodcalcium
examination.Allpatientsunderwentparathyroidresectioninaffectedside.Allthe21cases
appearedperioralandlimb numbness postoperatively and 5 cases ( 23.9% ) appearedlimb
convulsion.Conclusion Cliniciansshouldraiseawarenessofparathyroiddiseases.Theuseof neckcolorultrasoundcombined with bloodcalcium examinationhelpsthescreeningofthe
disease.Surgeryistheonlymeansoftreatingthedisease , andaccuratepositioningpreoperatively
isconducivetonarrowsurgeryproberangeandtominimizedamagetosurroundingtissues.

Key words: hyperparathyroidism , parathyroidneoplasms , diagnosis , therapy