河北医科大学学报

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布林佐胺滴眼液干预对妇科腹腔镜手术眼内压的影响

  

  1. 1.河北省石家庄市第三医院麻醉科,河北 石家庄 050011;2. 河北省石家庄市第三医院科教科,河北 石家庄 050011;
    3.河北省定州市第二医院骨科,河北 定州 073000;4. 河北省石家庄市妇幼保健院产科,河北 石家庄 050051
  • 出版日期:2016-07-25 发布日期:2016-08-11
  • 作者简介:左艳霞( 1981- ),女,河北石家庄人,石家庄市第三 医院主治医师,医学硕士,从事临床麻醉学研究。
  • 基金资助:
    河北省医学科学研究重点课题( 20150882)

The Brinzolamide treatment on intraocular pressure in gynecological laparoscopic operation

  1. 1.Department of  Anesthesiology, the Third Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang
    050011, China;2. Department of Science and Education, the Third Hospital of Shijiazhuang, Hebei
    Province, Shijiazhuang 050011, China; 3.Department of Orthopaedics, the Second Hospital of
    Dingzhou city,Hebei Provice,Dingzhou 073000,China; 4.Department of Obstetrics,
    Maternal and Child Care Service Centre of Shijianzhuang City,
    Hebei province, Shijiazhuang 050051 ,China
  • Online:2016-07-25 Published:2016-08-11

摘要: [摘要] 目的 探讨布林佐胺滴眼液对妇科腹腔镜手术中眼内压增高的调节作用。方法 选取美国麻醉师协
会分级 Ⅰ 或 Ⅱ 级妇科患有子宫肌瘤行腹腔镜子宫切除术患者 60 例作为研究对象,采用随机数字表法分为 2 组:布
林佐胺组(
n =30 )和对照组( n =30 )。监测 2 组全身麻醉后 5min ( T 0 ), T 位气腹且布林佐胺滴眼液滴眼或生理盐
水滴眼后 30min ( T 1 )、 60min ( T 2 )、 120min ( T 3 ),气腹结束后 30min ( T 4 )的眼内压( intraocularpressure , IOP ),同
时监测平均动脉压( meanarterialpressure , MAP )、心率(
heartrate , HR )、呼气末二氧化碳分压( end-tidalcarbon
dioxidepartialpressure , P ET CO 2 )和气道压力( airwaypressure , Paw )的变化。结果 2 组 IOP 均升高,但布林佐胺组
较对照组升高幅度小,
2 组组间、时点间以及组间·时点间交互作用差异均有统计学意义( P <0.05 );随着时间的
延长,
2 组 MAP 、 HR 和 P ET CO 2 、 Paw 均逐渐升高,其时点间差异有统计学意义( P <0.05 )。结论 妇科腹腔镜术中
应用布林佐胺滴眼液可降低眼压,预防视神经损伤,且对呼吸循环系统没有影响。

关键词: 眼内压, 妇科腹腔镜, 布林佐胺滴眼液

Abstract: [
Abstract ] Objective ToinvestigatetheeffectsofBrinzolamideontheintraocularpressure
(
IOP ) duringgynecologicallaparoscopicsurgery.Methods SixtycasesofASAgradeⅠ orⅡ
gynecologicalpatientswithuterinefibroidsunderwentlaparoscopichysterectomyweredivided
intotwogroups : thebrinzolamidegroup ( n =30 ) andthecontrolgroup ( n =30 ) accordingto
differentmodusoperandi.IOP , heartrate ( HR ), meanarterialpressure ( MAP ), end-tidalcarbon
dioxidepartialpressure ( P ET CO 2 ) andairway pressure ( Paw ) were measured5 minafter
anesthesia ( T 0 ), 30 min ( T 1 ), 60 min ( T 2 ) and120 min ( T 3 ) afterbrinzolamideeyedrops
(
brinzolamide ) treatment , pneumoperitoneum ( PP ) orabdominalwallwassuspended , 30 min
afterdeflationorabdominalwallwasputdown ( T 4 ) .Results IOPofthegroupAandgroupB wereincreasedsignificantlyatT 1 , T 2 andT 3 .Therewerestatisticallysignificantdifferencesinthe
interactionbetweengroupandtimepointsaswellasbetweengroups ( P <0.05 ) .MAP , HR , P ET
CO 2 andPawofthegroupAandgroupBwereincreasedsignificantlyatT 1 , T 2 , T 3 .Therewere
significantdifferences betweenthetime points ( P <0.05 ) .Conclusion Brinzolamidecan
effectively preventtheintraocular hypertension during gynecologicallaparoscopic surgery ,
preventopticnerveinjury , andhasnoeffectontherespiratoryandcirculatorysystem.

Key words:  intraocularpressure , laparoscopy , brinzolamide