河北医科大学学报

• 论著 • 上一篇    下一篇

血脂比值与TOAST分型及颅内血管狭窄程度的研究

  

  1. 1.河北医科大学第二医院神经内科，河北 石家庄 050000；2.河北省定州市第二医院神经内科，河北 定州 073000
  • 出版日期:2017-10-25 发布日期:2017-10-18
  • 作者简介:谷黎丽（1983-），女，河北定州人，河北省定州市第二医院主治医师，医学硕士研究生，从事神经内科疾病诊治研究。

Study of the relationship between bloodlipid ratio and TOAST classification & intracranial vascular stenosis#br#

  1. 1.Department of Neurology， the Second Hospital of Hebei Medical University， Shijiazhuang
    050000， China；2.Department of Neurology， the Second Hospital of Dingzhou City，
    Hebei Province, Dingzhou 073000, China
  • Online:2017-10-25 Published:2017-10-18

HTML

PDF (PC)

89

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗检测不同TOAST急性脑梗死患者血脂单项水平和血脂比值变化，探讨血脂单项水平和血脂比值在不同类型脑梗死急性期的作用及临床意义，并深入分析急性脑梗死患者血脂单项水平及血脂比值与颅内血管狭窄程度的关系。
〖HTH〗方法〖HTSS〗〖KG*2〗选取219例住院患者为病例组。将入选患者按照TOAST分型标准分为大动脉粥样硬化性梗死（largeartery atherosclerosis,LAA）95例、小动脉闭塞性梗死（smallartery occlusion lacunar,SAO）79例和心源性脑梗死（cardioembolism,CE）45例3个亚组。按梗死程度不同分为中度狭窄73例、重度狭窄57例和完全闭塞89例。测定所有患者血清总胆固醇（total cholestery,TC）、三酰甘油（triglyceride,TG）、低密度脂蛋白胆固醇（lowdensity lipoprotein，LDLC）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol,HDLC）单项血脂水平，并计算TC/HDLC、TG/HDLC、LDLC/HDLC血脂比值。
〖HTH〗结果〖HTSS〗〖KG*2〗 LAA型TC/HDLC比值高于CE型和SAO型，CE型高于SAO型，差异均有统计学意义（P＜005）； CE型TG/HDLC比值低于SAO型，差异有统计学意义（P＜005）。血清TC/HDLC比值在重度狭窄组最高，中度狭窄组血清TC/HDLC比值低于重度狭窄组,差异有统计学意义（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗 在TOAST亚型中，血清TG/HDLC比值可作为SAO型脑梗死发病早期判定病因学分类的预测指标。血清TC/HDLC比值有望成为LAA型脑梗死的特异性生化指标，对早期预测LAA型脑梗死有非常重要的临床价值。血清TC/HDLC比值对判断颅内血管重度狭窄具有重要参考价值。

关键词: 脑梗死, 椎基底动脉供血不足, 血脂异常

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the relationship between the levels of individual blood lipid/lipid ratio and the types of cerebral infarction as well as the severity of intracranial vascular stenosis in patients with acute cerebral infarction.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓 Two hundred and nineteen patients were included in the study. According to TOAST classification, all patients were divided into three  groups,  including 95  patients with large atherosclerotic(LAA), 79 patients with small arterial occlusive(SAO) and 45 patients with cardiogenicembolism(CE). According to the degree of infarction, 73 cases were moderate stenosis, 57 cases were severe stenosis, 89 cases were complete occlusion. The total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDLC) and high density lipoprotein cholesterol(HDLC) levels were measured and the ratios of TC/HDLC, TG/HDLC, and LDLC/HDLC were calculated.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓 The ratio of  TC/HDLC in LAA type of patients was significant higher than that in CE and SAO patients, and it was also higher in CE than in  SAO  patients(P＜005). The ratio of TG/HDLC in CE patients was significant lower than that in SAO(P＜005). The ratio of serum TC/HDLC was the highest in the severe stenosis group, and it was significant lower in the moderate stenosis patients than that in the severe stenosis patients(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓In the TOAST subtype, the serum TG/HDLC ratio can be used as a predictor of etiologic classification in the early onset of cerebral infarction in SAO type of patients. The TC/HDLC ratio is expected to be a specific biomarker of LAA, especially for early prediction of LAA. TC/HDLC ratio has an important reference value in judging severity of intracranial vascular stenosis.

Key words: brain infarction, vertebrobasilar insufficiency, dyslipidemia

版权所有 © 《河北医科大学学报》编辑部
本系统由北京玛格泰克科技发展有限公司设计开发