美托洛尔联合用药治疗慢性心力衰竭的效果研究#br#

doi:10.3969/j.issn.10073205.2019.04.006

河北医科大学学报

美托洛尔联合用药治疗慢性心力衰竭的效果研究#br#

1.石家庄医学高等专科学校冀联校区附属医院内科,河北石家庄 050071；2.石家庄医学高等专科学校生理教研室，
河北石家庄 050071；3.石家庄医学高等专科学校药理教研室,河北石家庄 050071

出版日期:2019-04-25 发布日期:2019-04-22
作者简介:于新龙（1979-），男，山东沂南人，石家庄医学高等专科学校冀联校区附属医院主治医师，从事心血管疾病诊治研究。

Study on the effect of Metoprolol combined with drugs in the treatment of chronic heart failure

1.Department of Medicine, Affiliated Hospital of Jilian Campus, Shijiazhuang Medical College,
Hebei Province, Shijiazhuang 050071, China; 2.Department of Physiology, Shijiazhuang Medical
College, Hebei Province, Shijiazhuang 050071, China; 3.Department of Pharmacology,
Shijiazhuang Medical College, Hebei Province, Shijiazhuang 050071, China

Online:2019-04-25 Published:2019-04-22

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨美托洛尔联合用药治疗慢性心力衰竭的效果及对患者心功能的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗选取慢性心力衰竭患者100例，随机分为2组各50例。对照组口服美托洛尔，研究组在美托洛尔的基础上联合复方强心汤进行治疗，对比2组心功能、临床疗效以及不良反应发生情况。
〖HTH〗结果〖HTSS〗〖KG*2〗研究组临床疗效和总有效率优于或高于对照组，差异均有统计学意义（P＜005）。治疗后研究组左心室舒张末期内径（left ventricular enddiastolic dimension，LVEDD）和左心室收缩末期内径（left ventricular endsystolic dimension，LVESD）水平明显低于治疗前和对照组，差异均有统计学意义（P＜005）。治疗后研究组左心室射血分数（left ventricular ejection fraction，LVEF）、左心室舒张早期充盈峰E峰/舒张晚期充盈的充盈峰A峰(E/A)和6分钟步行试验（6minute walking test，6MWT）水平明显高于治疗前和对照组，差异均有统计学意义（P＜005）。治疗后2组心型脂肪酸结合蛋白（heart fatty acid binding protein,HFABP）、正五聚蛋白3(pentraxin3,PTX3)、N末端脑钠肽前体(nervous terminal probrain natriuretic peptide,NTProBNP)明显低于治疗前和对照组，差异均有统计学意义（P＜005）。2组不良反应发生率差异无统计学意义（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗美托洛尔联合复方强心汤能有效改善患者心功能，且不良反应发生率低，值得进一步推广应用。

关键词: 心力衰竭, 美托洛尔, 复方强心汤

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the effect of metoprolol combined with drugs on chronic heart failure and cardiac function of patients.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred patients with chronic heart failure were randomly divided into two groups, 50 in each group. The control group was given metoprolol orally, while the study group was treated with compound Qiangxin Decoction on the basis of metoprolol. The cardiac function, clinical efficacy and adverse reactions of the two groups were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The clinical efficacy and total effective rate of the study group were higher than those of the control group, and the differences were statistically significant(P＜005). Left ventricular enddiastolic diameter(LVEDD) and left ventricular endsystolic dimension(LVESD) level after treatment in two groups were significantly lower than before treatment, the differences were statistically significant(P＜005). LVEDD and LVESD levels after treatment study group were significantly lower than the control group, the difference was statistically significant(P＜005). Left ventricular ejection fraction(LVEF), left ventricular diastolic filling peak E peak early/late diastolic filling of the filling A peak peak(E/A) and 6minute walking test(6MWT) after treatment study group were significantly higher than those before treatment and the control group, with statistically significant differences(P＜005). Heart fatty acid binding protein(HFABP), pentraxin3(PTX3), and nervous terminal probrain natriuretic peptide(NTProBNP) after treatment study group were significantly lower than before treatment and the control group(P＜005). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Metoprolol combined with compound Qiangxin Decoction can effectively improve the cardiac function of patients, and the incidence of adverse reactions is low, which should be further promoted and applied.

Key words: heart failure, metoprolol, compound Qiangxin Decoction

于新龙1，张永忠2，魏海青3*. 美托洛尔联合用药治疗慢性心力衰竭的效果研究#br#[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2019.04.006.

YU Xinlong1， ZHANG Yongzhong2， WEI Haiqing3*. Study on the effect of Metoprolol combined with drugs in the treatment of chronic heart failure[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2019.04.006.

[1]	王家琦, 刘立天（综述）, 张飞飞, 齐晓勇（审校）. 心力衰竭中心肌能量代谢的研究进展 [J]. 河北医科大学学报, 2022, 43(8): 962-965.
[2]	张文川. 铁调素/铁蛋白比值在预测维持性血液透析患者心功能的应用[J]. 河北医科大学学报, 2022, 43(5): 525-529.
[3]	王亚玲, 张杨, 郭安君, 饶明月, 张晓丹, 孟建康. 心脏永久性起搏器的不同起搏部位对植入患者心功能的影响[J]. 河北医科大学学报, 2022, 43(1): 22-25,30.
[4]	黄玲芳, 周松, 刘黎洁, 狄宁宁, 高艳周. 环磷腺苷葡胺结合磷酸肌酸钠治疗急性心肌梗死伴心力衰竭患者的效果及对CPP、sNEP表达的影响[J]. 河北医科大学学报, 2021, 42(12): 1382-1386.
[5]	张杨春, 符金娟, 蔡琳. 沙库巴曲缬沙坦钠治疗急性心肌梗死后心力衰竭效果观察[J]. 河北医科大学学报, 2021, 42(10): 1123-1127.
[6]	王亚玲，张杨，刘涛，郭安君，王梅. 螺内酯对慢性心力衰竭患者左心室功能及血清趋化素的影响[J]. 河北医科大学学报, 2020, 41(7): 749-753.
[7]	王海燕1，姜卫星2，田丽1，傅向华3. 沙库巴曲缬沙坦对急性前壁ST段抬高型心肌梗死PCI术后心力衰竭患者心功能的影响[J]. 河北医科大学学报, 2020, 41(3): 254-258,267.
[8]	吴学虹，邱朝霞. 危重症心力衰竭患者肺部感染的病原菌分布及其影响因素研究[J]. 河北医科大学学报, 2020, 41(3): 263-267.
[9]	辛秋平, 高志旭, 曲忠慧. 无创正压通气联合药物治疗急性左心衰竭的效果及对患者生物学标记物水平的影响[J]. 河北医科大学学报, 2020, 41(10): 1121-1125.
[10]	彭〓雪，王文娟，牛洁婷. 血清胎盘生长因子与老年慢性心力衰竭患者血清NTproBNP和近期预后的相关性分析[J]. 河北医科大学学报, 2019, 40(7): 768-772.
[11]	鲁志科1，孙〓榕2*. 不同剂量螺内酯对缺血性心肌病心力衰竭患者心脏结构和功能的影响[J]. 河北医科大学学报, 2018, 38(9): 1002-1006.
[12]	张〓楠，王玉通，李鲲鹏，白川盟，周继梧. β受体阻滞剂卡维地洛、美托洛尔对心力衰竭大鼠体液因子及ANP、TNFα、IL6、NE的影响分析[J]. 河北医科大学学报, 2018, 38(9): 1081-1084.
[13]	赵东坡，冯〓倩*，孙小燕，刘〓恒，张景鑫. 硝普钠、多巴胺、新活素三联用药治疗难治性心力衰竭的临床研究[J]. 河北医科大学学报, 2018, 38(3): 263-266,271.
[14]	葛南南（综述），汪和贵*（审校）. 脑啡肽酶抑制剂在心血管疾病中的最新研究进展#br#[J]. 河北医科大学学报, 2018, 39(2): 236-240.
[15]	马小宁，康志敏，胡晓宁，刘朝辉，王生池. 冻干重组人脑利钠肽治疗心力衰竭的效果观察#br#[J]. 河北医科大学学报, 2017, 37(7): 829-831.

美托洛尔联合用药治疗慢性心力衰竭的效果研究#br#

Study on the effect of Metoprolol combined with drugs in the treatment of chronic heart failure

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价