河北医科大学学报

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ATG16L1、Gal-9、IL-1β、IL-33在溃疡性结肠炎静息期和发病期的表达差异及临床意义

  

  1. 河北北方学院附属第一医院消化内科,河北 张家口 075000
  • 出版日期:2019-09-25 发布日期:2019-09-16
  • 作者简介:吴娜(1984-),女,河北武邑人,河北北方学院附属第一医院主治医师,医学硕士,从事消化内科疾病诊治研究。
  • 基金资助:
    河北省医学科学研究重点课题(20160368)

The difference of expression  of ATG16L1, Gal9, IL1β, IL33 in its resting and onset stage of ulcerative colitis and clinical significance#br#

  1. Department of Gastroenterology, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China
  • Online:2019-09-25 Published:2019-09-16

摘要: [摘要]
〖HTH〗目的〖HTSS〗〖KG*2〗 探讨自噬相关蛋白16样蛋白1(autophagy related protein 16 like protein 1,ATG16L1)、半乳糖凝集素9(galectin9,Gal9)、白细胞介素1β(interleukin1β,IL1β)、白细胞介素33(interleukin33,IL33)在溃疡性结肠炎(ulcerative colitis,UC)静息期和发病期的表达差异及临床意义。
〖HTH〗方法〖HTSS〗〖KG*2〗选择UC患者110例按照Mayo评分分为静息期UC组和发病期UC组,同时选择健康体检者40例作为对照组。比较3组血清ATG16L1、Gal9、IL1β、IL33水平,分析其与Mayo评分的相关性,并进行UC发病期的多因素Logistic多元回归分析。
〖HTH〗结果〖HTSS〗〖KG*2〗静息期UC组和发病期UC组血清IL1β、IL33、ATG16L1、Gal9水平显著高于对照组,发病期UC组血清IL1β、IL33、ATG16L1、Gal9水平显著高于静息期UC组,差异均有统计学意义(P<0.05)。血清IL1β、IL33、ATG16L1、Gal9水平与Mayo评分均呈正相关(P<0.05)。多因素Logistic 回归分析结果显示,血清IL1β、IL33、ATG16L1、Gal9是UC发病期的影响因素。
〖HTH〗结论〖HTSS〗〖KG*2〗发病期UC患者血清IL1β、IL33、Gal9、ATG16L1水平更高,可作为发病期UC的判断因素。

关键词: 结肠炎, 溃疡性;自噬;白细胞介素类;半乳糖凝集素类

Abstract: [Abstract]Objective〖HTSS〗To investigate the differential expression and clinical significance of autophagy related protein 16 like protein 1(ATG16L1), galectin9(Gal9), interleukin1β(IL1β) and interleukin33(IL33) in patients of ulcerative colitis(UC) at rest and onset.
〖HTH〗〖WTHZ〗Methods〖HTSS〗One hundred and ten patients with UC were selected as study group. According to the Mayo score,the patients were divided into the resting UC group and the onset UC group, and 40 healthy subjects were selected as the control group. The levels of serum ATG16L1, Gal9, IL1β and IL33 were compared between the three groups, and their correlation with the Mayo score was analyzed. Multivariate Logistic regression analysis of UC onset period was performed.
〖HTH〗〖WTHZ〗Results〖HTSS〗The serum levels of IL1β, IL33, ATG16L1, and Gal9 in the resting UC group and the onset UC group, were significantly higher than those in the control group(P<0.05), the active UC group was significantly higher than those of the resting UC group(P<0.05). The serum levels of IL1β, IL33, ATG16L1 and Gal9 were positively correlated with Mayo score(P<0.05). Multivariate logistic regression analysis showed that IL1β, IL33, ATG16L1, and Gal9 were the influencing factors of UC in the onset.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗The serum levels of IL1β, IL33, Gal9 and ATG16L1 are higher in patients with UC in the onset, which can be used as an independent judgment factor for UC in the onset.

Key words: colitis, ulcerative; autophagy; interleukins, galectins