清温饮联合更昔洛韦治疗小儿EB病毒感染的临床效果及对免疫功能的影响

doi:10.3969/j.issn.10073205.2017.01.009

河北医科大学学报

清温饮联合更昔洛韦治疗小儿EB病毒感染的临床效果及对免疫功能的影响

1.河北省沧州中西医结合医院药剂科，河北沧州 061001；2.河北省沧州市中心医院神经内科，河北沧州 061001；
3.河北省儿童医院感染消化科，河北石家庄 050031

出版日期:2017-01-25 发布日期:2017-02-08
作者简介:祁建平（1961-），男，河北沧州人，河北省沧州中西医结合医院副主任药师，医学学士，从事中药学研究。

Clinical efficacy of Ganciclovir combined Qing Wen decoction on the treatment of EB infection in children and its influence on immune function

1.Department of Pharmacy, Cangzhou Hospital of Traditional Chinese and Western Medicine, Hebei
Province, Cangzhou 061001, China； 2.Department of Neurology, Cangzhou Central Hospital,
Hebei Province, Cangzhou 061001,China； 3.Department of Infectious Diseases, Hebei
Children′s Hospital, Shijiazhuang 050031, China

Online:2017-01-25 Published:2017-02-08

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察清温饮联合更昔洛韦治疗小儿EB病毒感染的临床效果，并分析其对患儿免疫功能的影响，为EB病毒感染的中西医结合治疗提供依据。
〖HTH〗方法〖HTSS〗〖KG*2〗选择 80例EB病毒感染患儿作为研究对象，随机分为观察组和对照组，每组40例。对照组采用更昔洛韦治疗，观察组采用清温饮联合更昔洛韦治疗，比较2组治疗情况。
〖HTH〗结果〖HTSS〗〖KG*2〗观察组总有效率（95.0%）高于对照组（80.0%）（P＜005）。观察组退热时间、扁桃体肿大持续时间、咽痛消退时间、肝脾肿大消退时间、颈淋巴结肿大时间均短于对照组（P＜005）。2组EBVNAIgG治疗前后转阴情况无显著变化（P＞005），治疗后2组EBVDNA和EBVCAIgM转阴例数较治疗前显著增加（P＜005），且观察组增加例数明显多于对照组（P＜005）。与治疗前相比，2组治疗后ALT、AST和免疫球蛋白显著下降，且观察组下降程度高于对照组（P＜005）；2组治疗后淋巴细亚类相对于治疗前有明显改善，且治疗后观察组改善程度与对照组差异有统计学意义（P＜005）。治疗过程中2组不良反应发生率差异无统计学意义（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗清温饮联合更昔洛韦治疗小儿EB病毒感染疗效确切，患儿症状消退快，不良反应少，可有效降低EBDNA的含量，促进EB病毒的转化，对于减少患儿受感染后发生恶性疾患的风险具有重要意义。

关键词: 疱疹病毒4型, 人, 更昔洛韦, 清温饮

Abstract: ［Abstract］ Objective〖HTSS〗〓To observe the clinical effect of the Qing Wen decoction combined with ganciclovir on the treatment of children with EBV infection, and to analyze its influence on immune function, provide the basis for the treatment of EB virus infection with integrated traditional Chinese and Western Medicine.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Eighty cases of children with EB infection were selected and randomly divided into the observation group and the control group, 40 cases in each group. The control group patients were treated with ganciclovir, the observation group patients were treated by Qing Wen decoction combined with ganciclovir, treatment effects were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The total effective rate of the observation group and the control group were 95%，80%, and the difference in the effective rate between the two groups was statistically significant (P＜005). Compared with the control group, the improvement time of the observation group was significantly shorter (P＜005). Children EBVNAIgG negative before and after the treatment had no significant change (P＞005), but compared with before treatment, the number of EBVDNA and EBVCAIgM negative cases of the two groups of children significantly increased after treatment (P＜005), and the observation group increased the number of cases was significantly higher than that of control group (P＜005). Compared with before treatment, ALT, AST and immune globulin in two groups were decreased significantly after treatment, and the decreased degree in observation group was higher than that in the control group; lymphocyte subclass was improved significantly after treatment in two groups of children, and the improvement degree of the observation group was higher than that of the control group (P＜005). The adverse reaction rates in the two groups were not statistically significant (P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The effect of Qing Wen decoction combined with ganciclovir in treatment of children with EB infection is curative. Symptoms subside quickly in children. The drugs have less adverse reaction, can effectively reduce the EBDNA content, and promote the EB virus transformation. It is important to the reduce the risk of children infected after the occurrence of malignant disease.

Key words: herpesvirus 4, human, ganciclovir, Qing Wen decoction

祁建平1，祁晓媛2，王小娟3. 清温饮联合更昔洛韦治疗小儿EB病毒感染的临床效果及对免疫功能的影响[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2017.01.009.

QI Jianping1， QI Xiaoyuan2， WANG Xiaojuan3. Clinical efficacy of Ganciclovir combined Qing Wen decoction on the treatment of EB infection in children and its influence on immune function[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2017.01.009.

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清温饮联合更昔洛韦治疗小儿EB病毒感染的临床效果及对免疫功能的影响

Clinical efficacy of Ganciclovir combined Qing Wen decoction on the treatment of EB infection in children and its influence on immune function

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