河北医科大学学报

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盐酸法舒地尔联合银杏叶提取物治疗急性脑梗死的效果及对血清NSE的影响

  

  1. 1.河北省人民医院神经内科，河北 石家庄 050051；2.河北省人民医院心内科，河北 石家庄 050051；
    3.河北省人民医院妇二科，河北 石家庄 050051；4 .河北省疾病预防控制中心应急办，河北 石家 庄050021
  • 出版日期:2017-12-25 发布日期:2017-12-19
  • 作者简介:尹楠（1984-），女，河北保定人，河北省人民医院主治医师，医学硕士，从事神经内科疾病诊治研究。

Effects of fasudil hydrochloride combined with extract of Ginkgo Biloba on treatment of acute cerebral infarction and serum Level of NSE#br#

  1. 1.Department of Neurology， Hebei General Hospital, Shijiazhuang 050051， China; 2.Department of
    Cardiology， Hebei General Hospital, Shijiazhuang 050051, China; 3.The Second Department of
    Gynecology， Hebei General Hospital, Shijiazhuang 050051, China; 4.Department of
    Emergency Response Office， Hebei Provincial Center for Disease
    Control and Prevention， Shijiazhuang 050021, China
  • Online:2017-12-25 Published:2017-12-19

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察盐酸法舒地尔注射液联合银杏叶提取物注射液治疗急性脑梗死患者的临床效果及对血清神经元特异性烯醇化酶（neuron specific enolase，NSE）表达水平的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗将92例急性脑梗死患者随机分为联合组和对照组各46例。对照组在常规对症治疗基础上给予盐酸法舒地尔注射液治疗，联合组在对照组治疗基础上加用银杏叶提取物注射液治疗。2组均连续治疗14 d。比较2组临床疗效和总有效率，比较2组治疗前后脑卒中患者临床神经功能缺损程度评分（Clinical Neurological Deficit Scale，CNDS）和治疗前后血清NSE水平。
〖HTH〗结果〖HTSS〗〖KG*2〗 经过14 d的治疗，联合组临床疗效和总有效率均高于对照组，差异有统计学意义（P＜005）；治疗后2组 CNDS分数和血清NSE水平均较治疗前明显降低，治疗后联合组CNDS分数和血清NSE水平均低于对照组，差异有统计学意义（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗盐酸法舒地尔注射液联合银杏叶提取物注射液治疗急性脑梗死患者具有较好疗效，可显著降低其血清NSE水平，促进患者神经功能恢复，值得临床推广应用。

关键词: 脑梗死, 法舒地尔, 银杏叶

Abstract: ［Abstract］ Objective〖HTSS〗〓To study the clinical effect of fasudil hydrochloride combined with extract of Ginkgo Biloba on treatment of acute cerebral infarction and serum level of neuron specific enolase（NSE）.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Ninetytwo patients with acute cerebral infarction were randomly divided into combined group and control group, 46 cases in each group. Based on conventional symptomatic treatment, the control group used fasudil hydrochloride treatment. On the basis of the control group, the combined group was treated with extract of Ginkgo Biloba. Both groups were treated for 14 consecutive days. The clinical effects and total effective rates, the Clinical Neurological Deficit Scales(CNDSs) and serum levels of NSE of two groups before and after treatment were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After 14 days treatment, the clinical effect and total effective rate of the combined group were better than those of the control group, with differences between two groups(P＜0.05).The CNDSs and serum levels of NSE of two groups were significantly decreased after treatment, the CNDSs and serum levels of NSE of the combined group were much lower than those in the control group after treatment, presenting statistical significance(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Fasudil hydrochloride combined with extract of Ginkgo Biloba have good efficacy in treatment of acute cerebral infarction, and can significantly lower the level of NSE. It promotes the recovery of neural function and thus is worthy of clinical application.

Key words: brain infarction, fasudil, Ginkgo Biloba

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