河北医科大学学报

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自身抗体与慢性肾衰竭老年患者临床相关性分析

  

  1. 1.天津医科大学第二医院检验科,天津 300211;2.中国人民武装警察部队后勤学院附属医院呼吸和重症医学科,天津 300162
  • 出版日期:2017-08-25 发布日期:2017-08-09
  • 作者简介:刘双庆(1988-),男,天津人,天津医科大学第二医院技师,医学硕士,从事临床检验学研究。
  • 基金资助:
    天津市卫计委科技基金(2015kz101)

Clinical correlation analysis of autoantibodies and clinical symptom of elderly patients with chronic renal failure#br#

  1. 1.Department of Clinical Laboratory, the Second Hospital of Tianjin Medical University, Tianjin
    300211, China; 2.Department of Respiratory and Critical Care Medicine, Affiliated Hospital of
    Logistics University of Chinese People′s Armed Police Force, Tianjin 300162, China
  • Online:2017-08-25 Published:2017-08-09

摘要: 摘要]〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨自身抗体对慢性肾衰竭老年患者临床特征的影响,为临床诊疗提供参考。
〖HTH〗方法〖HTSS〗〖KG*2〗 将90例慢性肾衰竭老年患者根据自体抗体检测结果分为自身抗体阳性组46 例和自身抗体阴性组44 例,比较2组临床资料及实验室检查结果。
〖HTH〗结果〖HTSS〗〖KG*2〗阳性组局部感染和肾性骨病比例低于阴性组(P<005),部分器官切除术后比例高于阴性组(P<005)。Logistic回归分析结果显示,部分器官切除术后是产生自身抗体的独立危险因素(P<005),局部感染和肾性骨病是产生自身抗体的独立保护因素(P<005)。
〖HTH〗结论〖HTSS〗〖KG*2〗自身抗体对慢性肾衰竭老年患者临床症状有一定的影响,临床治疗中应给予重视。

关键词: 肾功能衰竭, 慢性;自身抗体;危险因素

Abstract: [Abstract]  Objective〖HTSS〗〓To understand the influence of autoantibodies on the clinical features of elderly patients with chronic renal failure, and to provide reference for clinical diagnosis and treatment.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Ninety elderly patients with chronic renal failure were divided into 2 groups according to the detection results of autoantibodies, including 46 cases of patients with autoantibodies(positive group) and 44 cases without autoantibody(negative group). The clinical data and laboratory results of the 2 groups were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The proportion of local infections and renal osteodystrophy in positive group was lower than that in negative group(P<005). The proportion of partial organ resection was higher than that of negative group(P<005). Logistic regression analysis revealed that partial organ resection was a independent risk factor of producing autoantibodies(P<005). Local infections and renal osteodystrophy were independent protective 〖JP2〗factors of producing autoantibodies(P<005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Autoantibodies have a certain influence〖JP〗 on the clinical symptoms of elderly patients with chronic renal failure, and attention should be paid in clinical treatment.

Key words: kidney failure, chronic, autoantibodies, risk factors