夏枯草胶囊治疗桥本甲状腺炎的效果及治疗前后甲状腺形态的超声诊断变

doi:10.3969/j.issn.10073205.2017.04.018

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察夏枯草胶囊治疗桥本甲状腺炎（Hashimoto thyroiditis,HT）的临床效果及治疗前后甲状腺形态的超声诊断变化。
〖HTH〗方法〖HTSS〗〖KG*2〗将72例桥本甲状腺炎随机分为研究组和对照组各36例。所有患者服用左旋甲状腺素钠片，研究组同时服用夏枯草胶囊，患者于治疗前、治疗后测定患者三碘甲腺原氨酸（free triiodothyronine，FT3）、游离甲状腺素（free thyroxine，FT4）、甲状腺激素（thyrotropin，thyroid stimulating hormone，TSH）水平和甲状腺过氧化物酶抗体（thyroid peroxidaseautoantibody，TPOAb）、甲状腺球蛋白抗体（thyroglobulinautoantibody，TGAb）抗体水平，比较组间差异。观察治疗前后患者甲状腺形态变化及不良反应发生情况。
〖HTH〗结果〖HTSS〗〖KG*2〗①治疗后2组FT3、FT4水平均较治疗前显著升高，TSH明显降低，研究组FT4、TSH改善程度显著优于对照组，差异有统计学意义（P＜005）。②治疗后研究组TPOAb、TGAb抗体水平均明显低于对照组，差异有统计学意义（P＜005）；2组TPOAb、TGAb水平均较治疗前明显降低，差异有统计学意义（P＜005）。③治疗后研究组甲状腺左右叶及峡部厚度均明显低于对照组，差异有统计学意义（P＜005）；2组各部位厚度均较治疗前明显减少，差异有统计学意义（P＜005）。④2组均未出现严重不良反应，2组不良反应发生率差异无统计学意义（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗夏枯草胶囊有利于显著改善HT患者甲状腺功能，降低甲状腺抗体水平，减少甲状腺各部位厚度，形态恢复正常，疗效确切。

关键词: 桥本病, 夏枯草胶囊, 甲状腺形态, 超声

Abstract: ［Abstract］ Objective〖HTSS〗〓To study the effect of Xiakucao capsule in the treatment of Hashimoto thyroiditis and changes of thyroid morphology by ultrasound diagnosis before and after treatment.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Seventytwo cases of pontine Hashimoto thyroiditis were randomly divided into study group and control group, 36 cases in each group. All patients taking levothyroxine sodium tablets, study group while taking selfheal capsule, all patients before treatment and after treatment at the same time determination of the patients with
free triiodothyronine(FT3), free thyroxine(FT4）, thyrotropin，thyroid stimulating hormone(TSH) levels and thyroid peroxidaseautoantibody(TPOAb）, thyroglobulinautoantibody(TGAb) antibody levels, differences between the groups were compared. In addition, the changes of thyroid morphology and adverse reactions were observed before and after treatment.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓①After treatment FT3, FT4 levels of patients in the two groups were increased and TSH were decreased. The improvement of FT4 and TSH in the study group was significantly better than that in the control group(P＜005). ②After treatment, the levels of TPOAb and TGAb in the study group were significantly lower than those in the control group(P＜005), and both in the two groups were significantly lower than those before treatment(P＜005). ③After treatment, thyroid lobes and isthmus thickness of patients in study group were significantly lower than those in control group(P＜005); at the same time, various parts of the thickness of study group was reduced, with statistically significant difference(P＜005). ④Serious adverse reactions and side effects were not found in patients, compared between groups, there were no significant difference of the incidence of adverse reactions.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Xiakucao capsule can improve thyroid function of patients with Hashimoto thyroiditis, and reduce the level of thyroid antibodies. The thickness of each part of the thyroid gland was significantly reduced and the morphology was normal.

Key words: Hashimoto disease, Xiakucao capsule, thyroid morphology, ultrasound

范智媛，张淋淋，米〓蕊. 夏枯草胶囊治疗桥本甲状腺炎的效果及治疗前后甲状腺形态的超声诊断变[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2017.04.018.

FAN Zhiyuan， ZHANG Linlin， MI Rui. Effect of Xiakucao capsule on Hashimoto thyroiditis and the ultrasonic diagnosis of thyroid morphology before and after treatment[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2017.04.018.

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夏枯草胶囊治疗桥本甲状腺炎的效果及治疗前后甲状腺形态的超声诊断变

Effect of Xiakucao capsule on Hashimoto thyroiditis and the ultrasonic diagnosis of thyroid morphology before and after treatment

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