河北医科大学学报 ›› 2023, Vol. 44 ›› Issue (8): 952-955,966.doi: 10.3969/j.issn.1007-3205.2023.08.015

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超声指标联合Framingham评分对强直性脊柱炎患者心血管受累风险的预测价值

  

  1. 河北中石油中心医院超声医学科，河北 廊坊 065000

  • 出版日期:2023-08-25 发布日期:2023-08-28
  • 作者简介:胡植双（1990-），女，河北廊坊人，河北中石油中心医院主治医师，医学学士，从事医学超声诊断研究。
  • 基金资助:
    廊坊市科学技术研究与发展计划项目（2021013045）

The value of ultrasonic index combined with Framingham score in predicting cardiovascular risk in patients with ankylosing spondylitis

  1. Department of Ultrasound Medicine, Hebei Petro China Central Hospital, Hebei Province, Langfang 065000, China

  • Online:2023-08-25 Published:2023-08-28

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摘要： 目的 探讨超声指标联合Framingham评分预测强直性脊柱炎患者心血管受累风险的价值。
方法 采用回顾性研究方法，选取我院治疗的强直性脊柱炎患者120例，随访期间发生心血管受累患者48例为观察组，无心血管受累患者72例为对照组，比较2组临床资料、颈动脉内膜厚度、颈动脉-股动脉脉搏传导速度（pulse wave velocity，PWV）、Framingham评分、强直性脊柱炎疾病活动指数（ankylosing spondylitis disease activity index，BASDAI）评分和强直性脊柱炎疾病功能指数（bath andylosing spondylitis function index，BASFI）评分差异。
结果 观察组年龄大于对照组，病程长于对照组，观察组长期激素治疗比例高于对照组（P＜0.05）。 观察组颈动脉内膜厚度、颈动脉-股动脉PWV、Framingham评分、BASDAI评分和BASFI评分明显高于对照组（P＜0.05）。病程、长期激素治疗、颈动脉内膜厚度、Framingham评分是强直性脊柱炎患者发生心血管受累的影响因素（P＜0.05）。该模型预测心血管受累发生ROC曲线下面积为0.826(95%CI：0.784~0.901，P＜0.05)，敏感度和特异度分别为70.0%和81.5%。
结论 强直性脊柱炎患者心血管受累发生受病程、长期激素治疗等因素的影响，同时颈动脉内膜厚度、Framingham评分等联合预测心血管受累发生有较好的价值。


关键词: 脊柱炎, 强直性, 超声指标, Framingham评分

Abstract: Objective To explore the value of ultrasonic index combined with Framingham score in predicting cardiovascular risk in patients with ankylosing spondylitis (AS). 
Methods Retrospective research methods were used, and 120 patients with AS treated in our hospital were selected. During the follow-up period, 48 patients with cardiovascular involvement were selected as the observation group, and 72 patients without cardiovascular involvement were selected as the control group. The clinical data, carotid intima thickness, carotid femoral pulse wave velocity (PWV), Framingham score, bath ankylosing spondylitis disease activity index (BASDAI) score and bath ankylosing spondylitis function index (BASFI) score of the two groups were compared. 
Results The age and course of the patients in the observation group were greater or longer than those in the control group, and the long-term hormone treatment rate in the observation group was higher than that in the control group (P＜0.05). The carotid intima thickness, carotid femoral PWV, Framingham score, BASDAI score and BASFI score in the observation group were significantly higher than those in the control group (P＜0.05). The course of disease, long-term hormone treatment, carotid intima thickness, and Framingham score were the influencing factors of cardiovascular involvement in patients with AS (P＜0.05). The area under the receiver operating characteristic (ROC) curve (AUC) of this model in predicting cardiovascular involvement was 0.826 (95%CI：0.784-0.901, P＜0.05), and the sensitivity and specificity were 70.0% and 81.5% respectively. 
Conclusion The occurrence of cardiovascular involvement in patients with AS is affected by the course of disease, long-term hormone treatment and other factors. In the meantime, carotid intima thickness, Framingham score and other factors in combination have good value in predicting the occurrence of cardiovascular involvement.


Key words: spondylitis, ankylosing, ultrasonic index, Framingham score

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