河北医科大学学报

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结直肠癌骨转移临床特点的Meta分析

  

  1. 1.天津铁厂职工医院骨科,河北 涉县 056404;2.河北医科大学第四医院外二科,河北 石家庄 050011
  • 出版日期:2017-09-25 发布日期:2017-09-18
  • 作者简介:曹红旗（1968-）,男，河南商丘人，天津铁厂职工医院主治医师，从事骨外科疾病诊治研究。

The clinical features of bone metastasis of colorectal cancer, A metaanalysis#br#

  1. 1.Department of Bone Section， the Worker′s Hospital of Tianjin Ironworks， Shixian 056404， China；
    2.The Second Department of Surgery， the Fourth Hospital of Hebei Medical Univsity， Shijiazhuang 050011， China
  • Online:2017-09-25 Published:2017-09-18

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨结直肠癌原发肿瘤位置及淋巴结分期与骨转移发生率的相关性。
〖HTH〗方法〖HTSS〗〖KG*2〗计算机检索万方数据库、清华同方全文数据库(CNKI)、维普数据库、Pubmed、Ovid、EMBASE及Medline等数据库，对符合纳入标准的文献应用RevMan 5.0软件进行Meta分析，同时按照不同原发部位以及淋巴结转移状态对各分析结果的OR值及95%CI进行计算。
〖HTH〗结果〖HTSS〗〖KG*2〗共纳入文献10篇，总样本量21 702例，其中直肠癌患者11 529例，结肠癌患者10 173例。Meta分析结果显示，直肠癌与结肠癌相比，骨转移发生率增高，OR值为1.91，95%CI为1.65~2.21；淋巴结阳性患者较淋巴结阴性患者更容易出现骨转移，OR值为3.22，95%CI为2.09~4.96。
〖HTH〗结论〖HTSS〗〖KG*2〗原发肿瘤位置和淋巴结转移状态与骨转移发生率相关。直肠癌以及淋巴结阳性患者更容易出现骨转移。

关键词: 结直肠肿瘤, 肿瘤转移, Meta分析

Abstract: ［Abstract］  Objective〖HTSS〗〓To explore the relationship between the incidence of bone metastasis and primary tumor location or lymph node stage for colorecatal carcinoma.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A systematic search was performed in Wanfang database, CNKI, Pubmed, Ovid, EMBASE and Medline. A metaanalysis was performed to generate the OR and 95%CI for the relationship using Review Manager 5.0.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓A total of 10 studies and 21 702 cases were enrolled in this metaanalysis. Our findings indicated that the patients with rectal cancer had a higher incidence of bone metastasis than the patients with colon cancer, the OR and 95%CI was 1.91 and 1.65-2.21. The patients with positive lymph node had a higher incidence of bone metastasis than the patients with negative lymph node ,the OR was 3.22, and 95%CI was 2.09-4.96.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Primary tumor location and lymph node stage were associated with the incidence of bone metastasis.

Key words: colorectal neoplasms, neoplasm metastasis, Metaanalysis

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