河北医科大学学报

• 论著 • 上一篇    下一篇

需要辅助通气的高危早产儿临床预后分析

  

  1. 河北省儿童医院新生儿科,河北 石家庄 050031
  • 出版日期:2017-09-25 发布日期:2017-09-18
  • 作者简介:蒲伟丛(1984-),女,河北无极人,河北省儿童医院主治医师,医学硕士,从事新生儿危重症诊治研究。
  • 基金资助:
    河北省医学科学研究重点课题(zd2013059);河北省医学适用技术跟踪项目(GL201664)

Clinical prognosis analysis of highrisk infants requiring assisted ventilation

  1. Department of Neonatology, Hebei Provincial Children′s Hospital, Shijiazhuang, 050031 China
  • Online:2017-09-25 Published:2017-09-18

摘要: [摘要]〓
〖HTH〗目的〖HTSS〗〖KG*2〗通过描述极低出生体质量儿病死率及主要不良预后支气管肺发育不良(bronchopulmonary dysplasia,BPD)的发生率,分析其发生的危险因素,为进一步改善预后提供依据。
〖HTH〗方法〖HTSS〗〖KG*2〗对新生儿重症监护病房收治的需要辅助通气的极低出生体质量儿139例临床资料进行分析。
〖HTH〗结果〖HTSS〗〖KG*2〗纳入患儿中BPD发生率为17.3%(24/139),总病死率为32.4%(45/139),BPD和(或)死亡发生率为41.0%(57/139),存活患儿中BPD发生率为25.5%。病死患儿中37例系家属放弃治疗后死亡。低胎龄、呼吸窘迫综合征(respiratory distress syndrome,RDS)、高新生儿急性生理学围产期补充评分(Score for Neonatal Acute Physiology Perinatal ExtensionⅡ,SNAPPEⅡ)、产前宫内感染为发生BPD和(或)死亡的独立危险因素。
〖HTH〗结论〖HTSS〗〖KG*2〗需要辅助通气的极低出生体质量儿病死率和(或)BPD发生率仍处于较高水平,放弃治疗是病死率高的主要原因。低胎龄、RDS、高SNAPPEⅡ、产前宫内感染为发生BPD和(或)死亡的高危因素。

关键词: 婴儿, 极低出生体重, 支气管肺发育不良, 危险因素

Abstract: [Abstract] Objective〖HTSS〗〓To study and to describe the mortality and incidence of bronchopulmonary dysplasia(BPD) of the very low birth weight infants (VLBWI) who required respiratory support.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Perinatal data and shortterm outcomes of 139 VLBWI were prospectively collected, all of whom were enrolled in the neonatal intensive care unit(NICU).
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The overall incidence of BPD was 17.3%(24/139). The overall inhospital mortality was 32.4%(45/139). The composite incidence of BPD and/or death was 41.0%(57/139). The incidence of BPD in the surviving children was 25.5%. Thirtyseven patients in the dead children died after the family abandoned treatment. Low gestational age, respiratory distress syndrome(RDS), high Score for Neonatal Acute Physiology Perinatal ExtensionⅡ(SNAPPEⅡ) and intrauterine infection were the independent risk factors for BPD and/or death.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The mortality and/or incidence of BPD of the VLBWI who required respiratory support remained high in this hospital. The withdrawal of care was a major contributor to the high mortality. Low gestational age, RDS, high SNAPPEⅡ and intrauterine infection were the independent risk factors for BPD and/or death.

Key words: infant, very low birth weight; bronchopulmonary dysplasia, risk factors