不同胎龄新生儿血清N端C型利钠尿肽前体和成骨标志物表达及意义

doi:10.3969/j.issn.10073205.2017.12.013

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨血清N端C型利钠尿肽前体（aminoterminal proCtype natriuretic peptide，NTproCNP）、骨碱性磷酸酶（bone specific alkaline phosphatase，BAP）、骨钙蛋白（osteocalcin，OC）在不同胎龄新生儿成骨中的作用及意义。
〖HTH〗方法〖HTSS〗〖KG*2〗选择生后24 h内新生儿80例，按胎龄分为A组（胎龄＜32周）、B组（32周≤胎龄＜37周）、C组（37周≤胎龄＜42周）；按出生身长百分位数分为身长小于胎龄儿组（小于同胎龄儿第10百分位数，L1组）、身长适于胎龄儿组（位于同胎龄儿10~90百分位数，L2组）、身长大于胎龄儿组（大于同胎龄儿第90百分位数，L3组）；按体质量百分位数分为体质量小于胎龄儿组（小于同胎龄儿第10百分位数，W1组）、体质量适于胎龄儿组（位于同胎龄儿10~90百分位数，W2组）、体质量大于胎龄儿组（大于同胎龄儿第90百分位数，W3组）。生后1 h内测量出生身长、体质量，24 h内测定血清NTproCNP、BAP及OC等指标。
〖HTH〗结果〖HTSS〗〖KG*2〗男性和女性新生儿胎龄、出生身长、体质量、NTproCNP、BAP及OC差异均无统计学意义（P＞005）；B、C组出生身长、体质量高于A组，C组出生身长、体质量高于B组，C组BAP低于A、B组（P＜005）；3组性别、NTproCNP、OC差异均无统计学意义（P＞005）；L3组BAP水平低于L1组和L2组（P＜005），3组间NTproCNP及OC水平差异均无统计学意义（P＞005）；W1、W2、W3组NTproCNP、BAP及OC水平差异均无统计学意义（P＞005）。新生儿出生体质量及身长均与胎龄呈正相关（P＜005），NTproCNP及OC与胎龄、出生体质量、身长及BAP无相关性（P＞005）；BAP与胎龄、体质量、身长呈负相关（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗未发现血清NTproCNP水平与妊娠中晚期胎儿骨生长发育的内在联系。BAP与胎儿骨骼生长发育密切相关，随着胎龄增加，胎儿成骨逐渐减弱。胎儿期骨矿化作用弱，新生儿骨强度小，可能有利于分娩。

关键词: 骨发育, 利钠肽, C型, 成骨标志物, 婴儿, 新生

Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the role and significance of aminoterminal proCtype natriuretic peptide(NTproCNP), bone specific alkaline(BAP) and osteocalcin(OC) in boneformation of neonates with different gestational age.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Eighty cases of neonates born within 24 hours were selected and were divided into group A(gestational age<32 weeks), group B(32 weeks ≤gestational age<37 weeks), and group C(37 weeks ≤ gestational age<42 weeks) according to gestational age. According to the body length participants were divided into three groups: length less than that of gestational age group(L1 group), length appropriate for gestational age group(L2 group), and length greater than the gestational age group(L3 group). According to body weight percentile, they were divided into three groups: body weight less than that of gestational age group(W1 group), body weight appropriate for gestational age group(W2 group), and body weight greater than gestational age group(W3 group). Birth length and body mass were measured within 1 hour after birth. Serum NTproCNP, BAP and OC were measured within 24 hours after birth.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There were no significant differences in gestational age, birth length, body mass, NTproCNP, BAP and OC between male and female neonates(P＞005). Participants from group B and C had higher birth length and body weight than A group. Participants from group C had higher birth length and body weight than group B. BAP of group C was lower than that of group A and B(P＜005). There was no significant difference in gender, NTproCNP and OC among 3 groups(P＞005). BAP of group L3 was lower than that of group L1 and L2(P＜005). There was no significant difference in the levels of NTproCNP and OC among 3 groups(P＞005); NTproCNP, BAP and OC level had no significant difference among group W1, W2 and W3(P＞005). Neonatal birth weight and body length were positively correlated with gestational age(P＜005). There were no correlation between NTproCNP and OC and gestational age, birth weight and BAP(P＞005). BAP and gestational age, body weight, and body length were negatively correlated(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓No relationship between serum NTproCNP levels and fetal bone development during the second and third trimester of pregnancy was found. BAP is closely correlated with fetal bone growth and development. With the increase of gestational age, fetal ossification gradually weakened. The mineralization of fetal bone is weak and the bone strength of newborn is samll, which may be beneficial to delivery.

Key words: bone development, natriuretic peptide, Ctype, osteogenic markers, infant, newborn

皮亚雷，张亚男，张会丰，阎〓雪*. 不同胎龄新生儿血清N端C型利钠尿肽前体和成骨标志物表达及意义[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2017.12.013.

PI Yalei, ZHANG Yanan, ZHANG Huifeng, YAN Xue*. The expression and significance of aminoterminal propeptide of Ctype natriuretic peptide and bone formation markers for neonates of different gestational age#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2017.12.013.

[1]	洪菲, 张伟艳, 朱媛媛, 宋磊. 局部脑组织氧监测联合磁共振多模态检查在早产儿脑损伤早期诊断中的临床研究 [J]. 河北医科大学学报, 2023, 44(5): 567-571.
[2]	房军臣, 李莉, 陈新, 蒲伟丛, 马莉, 邱向利. 高危早产儿肠外营养相关性胆汁淤积的危险因素及转归分析 [J]. 河北医科大学学报, 2023, 44(4): 444-449.
[3]	王占晖, 丁明欣, 柴清华, 刘雪. 不同冷光源光疗法对新生儿黄疸疗效、疾病转归进程的影响及不良反应分析 [J]. 河北医科大学学报, 2023, 44(4): 454-458.
[4]	邹良, 何秋红, 陈秋杨, 肖倩, 李兴洋, 金德华. IL-17/IL-23炎症轴在新生儿缺氧缺血性脑病发病中的作用机制探究 [J]. 河北医科大学学报, 2023, 44(3): 305-309.
[5]	刘雪, 王占晖, 高伟, 李克泉. 冷光源光疗法在足月新生儿黄疸中的治疗效果与安全性及对氧化/抗氧化系统的影响 [J]. 河北医科大学学报, 2023, 44(3): 310-314.
[6]	李雪景, 陈冬梅, 段佳良, 姚一民, 尚庆丽. 联合手术治疗增殖性糖尿病视网膜病变的继发性闭角型新生血管性青光眼的临床效果观察 [J]. 河北医科大学学报, 2023, 44(3): 319-323.
[7]	冯桐（综述）, 詹江华（审校）. 母乳喂养与新生儿坏死性小肠结肠炎发病及预后关系的研究进展 [J]. 河北医科大学学报, 2023, 44(2): 246-248,封三.
[8]	王婷婷, 郭华, 耿宝, 范雪爱. 机械通气与非机械通气新生儿血清sTREM-1、CC16水平对呼吸机相关性肺炎的预测价值 [J]. 河北医科大学学报, 2023, 44(10): 1178-1184.
[9]	董亚青, 高志敏, 徐然, 陈立芳, 袁静, 王明荣. 新生儿肺部超声在早产儿肺部感染评价中的价值 [J]. 河北医科大学学报, 2022, 43(9): 1047-1051.
[10]	路亮（综述）, 郭文香, 陈璐（审校）. 早产儿视网膜病变与早产小于胎龄儿关系的研究进展[J]. 河北医科大学学报, 2022, 43(5): 616-620,封三.
[11]	陈思敏, 刘鹏飞, 陆立东, 张新宇. 婴儿巨细胞病毒感染性肝炎病毒载量与γ-GGT的相关性及其对预后预测价值 [J]. 河北医科大学学报, 2022, 43(12): 1454-1458,1463.
[12]	杜志云, 史亦男, 许海娟, 李书秀. 血清miR-210与新生儿呼吸窘迫综合征严重程度和预后的关系 [J]. 河北医科大学学报, 2022, 43(11): 1277-1281,1310.
[13]	王娜, 田秀英, 王晓鹏. 超低出生体重儿入院低体温发生的危险因素及其与预后的关系研究[J]. 河北医科大学学报, 2022, 43(11): 1338-1342.
[14]	封纪珍, 贾立云, 王熙, 马翠霞, 封露露. 新生儿高甲硫氨酸血症串联质谱筛查结果及MAT1A基因突变分析[J]. 河北医科大学学报, 2021, 42(4): 410-414.
[15]	贾立云, 封纪珍, 王熙, 马翠霞, 封露露. 石家庄地区新生儿原发性肉碱缺乏症串联质谱筛查结果分析[J]. 河北医科大学学报, 2021, 42(3): 309-313.

不同胎龄新生儿血清N端C型利钠尿肽前体和成骨标志物表达及意义

The expression and significance of aminoterminal propeptide of Ctype natriuretic peptide and bone formation markers for neonates of different gestational age#br#

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价