河北医科大学学报 ›› 2023, Vol. 44 ›› Issue (3): 310-314.doi: 10.3969/j.issn.1007-3205.2023.03.013

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冷光源光疗法在足月新生儿黄疸中的治疗效果与安全性及对氧化/抗氧化系统的影响

  

  1. 山东省青岛市胶州中心医院儿科,山东 青岛 266300

  • 出版日期:2023-03-25 发布日期:2023-03-24
  • 作者简介:刘雪（1975-），女，山东胶州人，山东省青岛市胶州中心医院副主任医师，医学学士，从事新生儿疾病诊治研究。
  • 基金资助:
    青岛市医药卫生科研计划项目

Therapeutic effect and safety of cold light source phototherapy in full-term neonatal jaundice and its effect on oxidation and antioxidant system

  1. Department of Pediatrics, Jiaozhou Central Hospital, Shandong Province, Qingdao 266300, China
  • Online:2023-03-25 Published:2023-03-24

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摘要： 目的 探讨冷光源光疗法在足月新生儿黄疸中的治疗效果与安全性及对氧化抗氧化系统的影响。
方法  选取我院足月新生儿黄疸患儿480例，按照随机数字表法分为对照组、观察组各240例。对照组给予普通蓝光灯光疗，观察组给予冷光源光疗。比较2组治疗效果、康复进程、治疗前后胆红素指标［血清总胆红素（total serum bilirubin，TSB）、结合胆红素（conjugated bilirubin，DBIL）、间接胆红素（indirect bilirubin，IBIL）］、血清转铁蛋白（serum transferrin，TRF）、氧化/抗氧化系统指标［丙二醛（malondialdehyde，MDA）、超氧化物歧化酶（superoxide dismutase，SOD）、8-羟-2-脱氧鸟苷（8-hydroxy-2-deoxyguanosine，8-OHdG）］、患儿生长发育情况及不良反应。
结果 观察组总有效率96.25%高于对照组90.00%（P＜0.05）；观察组黄疸消退时间、胆红素恢复正常时间、住院时间短于对照组（P＜0.05）；治疗3 d后、治疗5 d后与对照组相比，观察组血清DBIL、TSB、IBIL水平较低，TRF较高（P＜0.05）；治疗3 d后、治疗5 d后观察组血清8-OHdG、MDA水平低于对照组，血清SOD水平高于对照组（P＜0.05）；观察组发热、皮疹、腹泻、脱水、烦躁哭闹发生率低于对照组（P＜0.05）；治疗后3个月观察组患儿体重、身长、头围高于对照组（P＜0.05）。
结论 冷光源光疗法可提高足月新生儿黄疸的治疗效果，减轻机体氧化损伤，加速患儿体内胆红素代谢水平，且不良反应少，有助于促进患儿身体发育。

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Abstract: Objective To investigate the therapeutic effect and safety of cold light source phototherapy in full-term neonatal jaundice and its effect on oxidation and antioxidant system. 
Methods A total of 480 full-term infants with neonatal jaundice in our hospital were selected and divided into the control group (n=240) and the observation group (n=240) according to the random number table method. The control group was given ordinary blue light phototherapy, and the observation group was given cold light source phototherapy. The therapeutic effect, rehabilitation process, bilirubin indexes ［total serum bilirubin (TSB), conjugated bilirubin (DBIL), indirect bilirubin (IBIL)］, serum transferrin (TRF), oxidation and antioxidant system indicators ［malondialdehyde (MDA), superoxide dismutase (SOD), 8-hydroxy-2-deoxyguanosine (8-OHdG)］, children′s growth and development and adverse reactions were compared between two groups. 
Results The total effective rate of the observation group was 96.25%, which was higher than that (90.00%) of the control group (P＜0.05). Time to jaundice subsidence, time to bilirubin recovery, and length of hospitalization in the observation group were shorter than those in the control group (P＜0.05). Compared with the control group, the serum levels of DBIL,TSB and IBIL in the observation group were lower, and the TRF was higher (P＜0.05) at 3 d and 5 d after treatment. The serum levels of 8-OHdG and MDA in the observation group were lower than those in the control group, while the serum SOD level was higher than that in the control group at 3 d and 5 d after treatment (P＜0.05). The incidence of fever, rash, diarrhea, dehydration, irritability and crying in the observation group was lower than that in the control group (P＜0.05). Body weight, length and head circumference of the observation group were higher than those of the control group at 3 months after treatment (P＜0.05). 
Conclusion Cold light source phototherapy can improve the therapeutic effect of full-term neonatal jaundice, reduce the oxidative damage in the body, accelerate the metabolism of bilirubin in the body, and has few adverse reactions, which is helpful to promote the physical development of children. 


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