河北医科大学学报

• 论著 • 上一篇    下一篇

非小细胞肺癌中HIF-1α和Vimentin的表达及其临床意义

  

  1. 1.河北省人民医院肿瘤五科，河北 石家庄 050051；2.河北省人民医院公费医保办公室，河北 石家庄 050051；
    3.河北省人民医院科教处，河北 石家庄 050051；4. 河北省人民医院胸外二科，河北 石家庄 050051
  • 出版日期:2018-05-25 发布日期:2018-05-30
  • 作者简介:张洪珍(1966-)，女，河北衡水人，河北省人民医院主任医师，医学博士，从事肿瘤疾病诊治研究。
  • 基金资助:
    河北省医学科学研究重点课题（ZD20140478）

Expression and clinical significance of HIF1α and Vimentin in nonsmall cell lung cancer#br#

  1. 1.The Fifth Department of Oncology, Hebei General Hospital,Shijiahzuang 050051, China;
    2.Department of Public Health Insurance, Hebei General Hospital, Shijiahzuang 050051,
    China; 3.Department of Science and Education, Hebei General Hospital, Shijiahzuang
    050051, China； 4.The Second Department of Thoracic Surgery， Hebei
    General Hospital, Shijiahzuang 050051, China
  • Online:2018-05-25 Published:2018-05-30

HTML

PDF (PC)

156

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗研究缺氧诱导因子1α（hypoxiainducible factor 1α,HIF1α）和Vimentin在非小细胞肺癌（nonsmall cell lung cancer,NSCLC）组织中的表达及与临床病理特征的关系。
〖HTH〗方法〖HTSS〗〖KG*2〗应用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶连接法检测NSCLC组织和癌旁组织HIF1α和Vimentin的表达，分析其与临床病理特征间的关系。
〖HTH〗结果〖HTSS〗〖KG*2〗NSCLC组织中HIF1α和Vimentin的阳性表达率分别为80.0%（48/60）和66.7%（40/60），显著高于癌旁组织中的阳性表达率5.0%（1/20）和10.0%（2/20），差异有统计学意义（P＜005）；HIF1α在低未分化、高TNM分期的NSCLC组织中的表达明显增高（P＜005），Vimentin在高TNM分期和有淋巴结转移的NSCLC组织中的表达明显增高（P＜005）；NSCLC组织中HIF1α与Vimentin的表达呈正相关（rs=0.354,P=0.006）。
〖HTH〗结论〖HTSS〗〖KG*2〗HIF1α和Vimentin蛋白在NSCLC组织中过表达，与NSCLC进展密切相关，二者联合检测可作为NSCLC预后的判断指标。

关键词: 癌, 非小细胞肺, 缺氧诱导因子1&alpha, 波形蛋白

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the expression of HIF1α and Vimentin in nonsmall cell lung cancer(NSCLC) and its relationship with clinicopathological features.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The expression of HIF1α and Vimentin in nonsmall cell lung cancer tissues and paracancerous tissues was detected by immunohistochemical streptavidinperoxidaselinked method to analyze the relationship between clinical and pathological features.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive rates of HIF1α and Vimentin in nonsmall cell lung cancer were 80.0%(48/60) and 66.7%(40/60), respectively, which were significantly higher than those in paracancerous tissues 5.0%(1/20) and 10.0%(2/20) , the difference was statistically significant(P＜005). The expression of HIF1α was significantly higher in NSCLC tissues with low undifferentiated and high TNM stages(P＜005). The expression of Vimentin was significantly higher in NSCLC tissues with high TNM staging and lymph node metastasis(P＜005). There was a positive correlation between the expression of HIF1α and Vimentin in NSCLC tissues(rs=0354, P=0.006).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The overexpression of HIF1α and Vimentin is closely related to the progression of nonsmall cell lung cancer. The combined detection of HIF1α and Vimentin can be used as a prognostic indicator of nonsmall cell lung cancer.

Key words: carcinoma, nonsmallcell lung, hypoxiainducible factor1α, Vimentin

版权所有 © 《河北医科大学学报》编辑部
本系统由北京玛格泰克科技发展有限公司设计开发