关键词: 腹主动脉瘤, 腔内治疗, 血清因子

Abstract: ［Abstract］Objective〖HTSS〗To investigate the effects of endovascular treatment of abdominal aortic aneurysm on serum T lymphocyte subsets, interleukin-6(IL-6), regulated upon activation normal T-cell expressed and secreted(RANTES) and phosphoinositide 3-kinas(PI3K) levels.
〖HTH〗〖WTHZ〗Methods〖HTSS〗One hundred patients with abdominal aortic aneurysm were retrospectively analyzed for clinical case data. According to different treatment methods, they were divided into control group(n=49) and observation group(n=51). The patients in the control group were treated with conventional open surgery, and the patients in the observation group were treated with endovascular aneurysm repair. Serum factors(IL-10, IL-6, hs-CRP, RANTES, TNF-α, PI3K), serum T cell subsets(CD3+, CD4+, CD8+, CD4+/CD8+), blood lipids(TC, TG, HDL-C, LDL-C) levels were compared between the two groups. The perioperative index values(intraoperative bleeding, operation time, postoperative fasting time, total hospitalization time) and postoperative complications(pulmonary complications, water and electrolyte disorders, infection, digestive system complications) were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗Before treatment, there was no significant difference in each index between the two groups(P＞0.05). After treatment, CD3+, CD4+, and CD4+/CD8+ in the two groups were significantly higher than those before treatment, and CD8+ were significantly lower than those before treatment. CD3+, CD4+, CD4+/CD8+ in the observation group were significantly higher than those in the control group, and CD8+ was significantly lower than that in the control group(P＜0.05). The level of IL-6, RANTES, PI3K factor in the two groups was significantly lower than that before treatment, and the level of IL-6, RANTES, PI3K factor in the observation group was significantly lower than that in the control group(P＜0.05).  The level of TC, TG, LDL-C in the two groups was lower than that before treatment, and the level of HDL-C was higher than that before treatment. The TC, TG, LDL-C in the observation group was lower than that in the control group, and the HDL-C in the observation group was higher than that in the control group(P＜0.05).  The level of hs-CRP, TNF-α in the two groups was lower than that before treatment. The level of IL-10 was higher than that before treatment, and the level of hs-CRP, TNF-α in the observation group was lower than that in the control group, and the level of IL-10 in the observation group was higher than that in the control group(P＜0.05). Those values about intraoperative and postoperative index values(intraoperative blood loss, operation time, postoperative fasting time, total hospitalization time) in the observation group were significantly better than the control group(P＜0.05).  The incidence of postoperative complications(pulmonary complications, water-electrolyte disorders, infection, digestive system complications) was significantly lower in the observation group than that in the control group(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗Endovascular treatment of abdominal aortic aneurysm can effectively improve the T lymphocyte subsets, and reduce IL-6, RANTES and PI3K factors. The effect is significant, safe and reliable.

Key words: abdominal aortic aneurysm； endovascular treatment, serum factors