河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (4): 425-428.doi: 10.3969/j.issn.1007-3205.2021.04.012

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干眼症患者泪液IL-1β、TNF-α、TSLP水平与BUT值、FL评分的相关性分析

  

  1. 1.广东省汕头市中心医院，中山大学附属汕头医院眼科，广东 汕头 515031；
    2.广东省汕头市中心医院，中山大学附属汕头医院西药库，广东 汕头 515031
  • 出版日期:2021-04-25 发布日期:2021-04-29
  • 作者简介:黄锐升（1983-），男，广东揭阳人，广东省汕头市中心医院主治医师，医学硕士，从事眼科疾病诊治研究。
  • 基金资助:
    汕头市医疗卫生自筹经费科技计划项目(汕府科［2017］119号-20)

Correlation analysis of IL-1β, TNF-α, TSLP levels in tear fluid with BUT value, FL score in patients with dry eye

  1. 1.Department of Ophthalmology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-Sen 
    University, Guangdong Province, Shantou 515031, China; 2.Department of Western Medicine Storehouse, 
    Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-Sen University,  
    Guangdong Province, Shantou 515031, China
  • Online:2021-04-25 Published:2021-04-29

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摘要： 目的  探讨干眼症患者泪液白细胞介素1β（interleukin-1β，IL-1β）、肿瘤坏死因子α（tumor necrosis factor-α,TNF-α）、胸腺基质淋巴细胞生成素（thymic stromal lymphopoietin,TSLP）水平与泪膜破裂时间（break-up time,BUT）值、角膜荧光素染色（corneal fluorescein staining,FL）评分的相关性。
方法  选择干眼症患者120例为研究组，同期健康志愿者100例为对照组。采集泪液，检测IL-1β、TNF-α、TSLP水平，比较2组BUT值及FL评分。分析泪液IL-1β、TNF-α、TSLP水平与BUT值、FL评分的相关性。
结果  研究组泪液IL-1β、TNF-α、TSLP水平均显著高于对照组，差异有统计学意义（P＜0.05）。研究组BUT值明显低于对照组，FL评分明显高于对照组，差异有统计学意义（P＜0.05）。Pearson相关分析结果显示，泪液IL-1β、TNF-α、TSLP水平与BUT值呈显著负相关（P＜0.01），与FL评分呈显著正相关（P＜0.01）。ROC曲线显示，泪液IL-1β、TNF-α、TSLP水平对干眼症具有一定诊断价值（AUC=0.830，0.885，0.838，P＜0.01），且三项联合（AUC=0.920，P＜0.01）诊断价值较高。
结论  干眼症患者泪液IL-1β、TNF-α、TLSP水平与BUT值、FL评分均显著相关，IL-1β、TNF-α、TLSP水平升高导致泪膜稳定性降低及眼表损伤，联合检测泪液IL-1β、TNF-α、TLSP水平可用于干眼症的辅助诊断。


关键词: 干眼病, 白细胞介素1β, 肿瘤坏死因子α

Abstract: Objective  To investigate the correlation of the levels of interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α) and thymic stromal lymphopoietin(TSLP) in tear fluid of patients with dry eye with tear film break-up time(BUT) value and corneal fluorescein staining(FL) score. 
Methods  A total of 120 patients with dry eye were selected as the research group, and 100 healthy volunteers during the same period were selected as the control group. Tear fluid was collected, IL-1β, TNF-α, TSLP levels were detected, and the BUT value and FL score of the two groups were compared. The correlation of IL-1β, TNF-α, TSLP levels in tear fluid with BUT value and FL score was analyzed. 
Results  The levels of IL-1β, TNF-α and TSLP in tear fluid of the research group were significantly higher than those of the control group, and the difference was statistically significant(P＜0.05). The BUT value of the research group was significantly lower than that of the control group, while the FL score was significantly higher than that of the control group, with significant difference(P＜0.05). Pearson correlation analysis results showed that IL-1β, TNF-α, TSLP levels in  tear fluid were significantly and negatively correlated with BUT values(P＜0.01), but significantly and positively correlated with FL scores(P＜0.01). The ROC curve revealed that the levels of IL-1β, TNF-α, and TSLP in tear fluid had a certain diagnostic value for dry eye(AUC=0.830, 0.885, 0.838, P＜0.01), and the diagnostic value of the combination of the three was higher(AUC=0.920, P＜0.01). 
Conclusion  The levels of IL-1β, TNF-α and TLSP in the tear fluid of patients with dry eye are significantly correlated with the BUT value and FL score. Increased levels of IL-1β, TNF-α and TLSP lead to a decrease in tear film stability and ocular surface damage. Combination detection of the levels of IL-1β, TNF-α and TLSP in tear fluid can be used for the auxiliary diagnosis of dry eye.

Key words: dry eye disease, interleukin-1β, tumor necrosis factor-α

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