河北医科大学学报 ›› 2022, Vol. 43 ›› Issue (3): 280-285.doi: 10.3969/j.issn.1007-3205.2022.03.007

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维生素D受体基因多态性与代谢综合征相关性的Meta分析

  

  1. 1.河北医科大学研究生学院2020级学硕4班，河北 石家庄 050017；2.河北省疾病预防控制中心慢性非传染性疾病防治所， 河北 石家庄 050024；3.华北理工大学公共卫生学院流行病学与卫生统计学教研室，河北 唐山 063210

  • 出版日期:2022-03-25 发布日期:2022-04-14
  • 作者简介:韦琴（1997-），女，广西南宁人，河北医科大学公共卫生学院医学硕士研究生，从事非传染性疾病分子流行病学研究。
  • 基金资助:

    河北省医学科学研究课题计划（20200689）

Meta-analysis of the correlation between gene polymorphism of vitamin D receptor and metabolic syndrome

  1. 1.Grade 2020, the Graduate School of Hebei Medical University, Hebei Province, Shijiazhuang 050017，

    China; 2.Institute of Chronic Non-communicable Disease Prevention and Control, Hebei Provincial

    Center for Disease Control and Prevention, Hebei Province, Shijiazhuang 050024，China;

    3.Department of Epidemiology and Statistics, College of Public Health, North China University of Science and Technology, Hebei Province, Tangshan 063210， China

  • Online:2022-03-25 Published:2022-04-14

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摘要：

目的  探讨维生素D受体（vitamin D receptor，VDR）基因多态性与代谢综合征（metabolic syndrome，MetS）遗传易感性的关系。

方法 截止2021年3月，联合检索PubMed、中国知网、万方和中国生物医学文献数据库中有关FokI rs2228570 G＞A、BsmI rs1544410 G＞A与MetS易感性关联的研究。采用Stata12.0统计软件进行Meta分析，以合并优势比（odds ratio，OR）及其95%CI评估关联强度。

结果 最终纳入9篇文献，包括4 239例研究对象。Meta分析结果显示，FokI rs2228570多态性可显著增加MetS遗传易感性，在等位基因模型（f vs. F）、显性模型（ff+Ff vs. FF）、隐性模型（ff vs. Ff+FF）及纯合子模型（ff vs. FF）下，OR及其95%CI分别为1.25（1.07~1.46）、1.25（1.09~1.44）、1.40（1.10~1.77）、1.51（1.13~1.03）；BsmI rs1544410多态性可显著降低MetS遗传易感性，在等位基因模型（b vs. B）及杂合子模型（Bb vs. BB）下，OR及其95%CI分别为0.86（0.76~0.98）、0.77（0.62~0.95）。

结论 VDR基因多态性与MetS遗传易感性关系密切。FokI f等位基因可能是MetS发病的危险因素，BsmI b等位基因可能是MetS发病的保护因素。

关键词:

代谢综合征, 受体, 骨化三醇, Meta分析

Abstract:

Objective To explore the relationship between the gene polymorphism of vitamin D receptor(VDR) and genetic susceptibility to metabolic syndrome(MetS).

Methods Pubmed, CNKI, Wanfang and Chinese Biomedical Literature Database were searched to obtain the related articles about the relationship between FokI rs2228570 G＞A, BsmI rs1544410 G＞A polymorphism and MetS susceptibility up to March 2021. Stata12.0 statistical software was used for meta-analysis. Combined odds ratio(OR) and its 95% confidence interval(95%CI) were used to evaluate the correlation strength.

Results A total of 9 articles with 4 239 subjects were included. The results of meta-analysis showed that the FokI rs2228570 polymorphism could significantly increase the genetic susceptibility to MetS; in allele model(f vs. F), dominant model(ff+Ff vs. FF), recessive model(ff vs. Ff+FF) and homozygous model(ff vs. FF), the OR and 95%CI were 1.25(1.07-1.46), 1.25(1.09-1.44), 1.40(1.10-1.77) and 1.51(1.13-1.03), respectively. The BsmI rs1544410 polymorphism could significantly decline the genetic susceptibility to MetS; in allele model(b vs. B) and heterozygous model(Bb vs. BB), the OR and 95%CI were 0.86(0.76-0.98) and 0.77(0.62-0.95), respectively.

Conclusion VDR gene polymorphism is significantly related to genetic susceptibility to MetS. FokI f allele may be a risk factor for MetS, and BsmI b allele may be a protective factor for MetS.

Key words: metabolic syndrome, receptors, calcitriol, meta-analysis

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