河北医科大学学报 ›› 2022, Vol. 43 ›› Issue (5): 578-582.doi: doi:10.3969/j.issn.1007-3205.2022.05.016

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＜3个月婴儿胃食管反流病的临床特征及莫沙必利对其疗效分析

  

  1. 安徽医科大学附属安庆医院儿科，安徽 安庆 246000
  • 出版日期:2022-05-25 发布日期:2022-05-30
  • 作者简介:何平（1988-），男，安徽安庆人，安徽医科大学附属安庆医院主治医师，医学硕士，从事儿内科疾病诊治研究。
  • 基金资助:
    安徽医科大学校科研基金(2018xkj081)；安庆市第二批自筹经费科技计划项目（2018Z2015）

Clinical features of gastroesophageal reflux disease in infants less than 3 months of age and analysis of the efficacy of mosapride

  1. Department of Pediatrics, Anqing Hospital Affiliated to Anhui Medical University, Anqing 246000, China
  • Online:2022-05-25 Published:2022-05-30

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摘要：

目的  利用24 h食管pH监测＜3个月婴儿胃食管反流病(gastroesophagealreflux disease,GERD)，提高其精确率，对GERD患儿加用莫沙必利口服，减轻GERD的相关临床症状。

方法  对怀疑GERD的49例患儿（＜3个月）使用24 h食管pH监测其特征，同时对GERD患儿进行莫沙必利口服治疗并判断其治疗效果。

结果  49例怀疑GERD患儿中，符合GERD 33例（67.3%）；而在GERD患儿中，新生儿有23例，明显高于非新生儿的结果（P＜0.05）；其中GERD临床表现以呕吐为主占88.2%，咳嗽表现占41.2%；而在新生儿期GERD患儿其酸暴露频率以及连续酸暴露的持续时间较非新生儿期增大（P＜0.05）；与胃食管反流（gastroesophageal reflux,GER）阴性患者相比，莫沙必利对GER阳性患儿的应用有明显显著效果, GER阳性组患儿治疗有效率显著高于GER阴性组（P＜0.05），血清胃泌素和血浆胃动素水平显著高于GER阴性组（P＜0.05），呕吐发生频率明显低于GER阴性组（P＜0.05）。

结论  24 h食管动态pH监测技术仍是对婴儿GERD的诊断的精确方法，而莫沙必利对婴儿GERD具有明显疗效，能够促进患儿早期生长发育的发展和恢复。

关键词: 胃食管反流, 氢离子浓度, 莫沙必利

Abstract:

Objective  To monitor gastroesophageal reflux disease(GERD) in infants less than 3 months of age by 24-hour esophageal pH to improve its accuracy,and to relieve clinical symptoms of GERD by administering oral mosapride to children with GERD.

Methods   For 49 children with suspected GERD(<3 months of age), 24-hour esophageal pH monitoring was used to monitor its characteristics, and children with GERD were orally administered with mosapride to evaluate its efficacy.

Results   Of 49 children with suspected GERD, 33 were eligible for GERD, accounting for 67.3%; among children with GERD, 23 of them were neonates, which was significantly higher than that of non-neonates(P＜0.05).The clinical manifestations of GERD were vomiting, accounting for 88.2%, and coughing, accounting for 41.2%. The frequency of acid exposure and duration of continuous acid exposure in infants with neonatal GERD increased as compared with non-neonates(P＜0.05). Compared with GER-negative patients, mosapride had a significant effect on GER-positive children. The effective rate, serum gastrin and plasma motilin levels in GER-positive children were significantly higher than those in GER-negative children(P＜0.05), while the incidence of vomiting in GER-positive children was significantly lower than that in GER-negative children(P＜0.05).

Conclusion  24-hour esophageal dynamic pH monitoring technology is still an accurate method for the diagnosis of GERD in infants. Mosapride has an obvious therapeutic effect on GERD of infants, which can promote the development and recovery of early growth and development of infants.

Key words: gastroesophageal reflux, hydrogen-ion concentration, mosapride

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