河北医科大学学报 ›› 2023, Vol. 44 ›› Issue (3): 264-267,273.doi: 10.3969/j.issn.1007-3205.2023.03.004

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G-17、SOX-2、HSP70在Hp感染胃炎中的表达及意义

  

  1. 河北省廊坊市人民医院消化科,河北 廊坊 065000

  • 出版日期:2023-03-25 发布日期:2023-03-24
  • 作者简介:杜丙杰(1990-),男,山东汶上人,河北省廊坊市人民医院主治医师,医学学士,从事消化科疾病诊治研究。
  • 基金资助:
    河北省医学科学研究课题计划(20221596)

Expression and significance of G-17, SOX-2 and HSP70 in Hp-infected gastritis

  1. Department of Gastroenterology, Langfang People′s Hospital, Hebei Province, Langfang 065000, China
  • Online:2023-03-25 Published:2023-03-24

摘要: 目的 探讨胃泌素17(gastrin-17,G-17)、性别决定区Y框蛋白2(sex-determining region Y box protein-2,SOX-2)、热休克蛋白70(heat shock protein 70,HSP70)在幽门螺杆菌(helicobacter pylori,Hp)感染胃炎中的表达及意义。
方法 选取慢性胃炎患者90例,根据是否合并Hp感染将其分为Hp阳性组和Hp阴性组,每组45例。比较2组一般资料,G-17、HSP70水平及SOX-2、HSP70表达情况。分析Hp阳性患者G-17、SOX-2、HSP70与各指标的相关性;多因素Logistic回归分析影响Hp感染胃炎的危险因素。
结果 Hp阳性组共餐饮食方式比例、临床症状积分高于Hp阴性组,胃蛋白酶原Ⅰ(pepsinogen Ⅰ,PG-Ⅰ)、胃蛋白酶原Ⅱ(pepsinogen Ⅱ,PG-Ⅱ)水平低于Hp阴性组(P<0.05)。Hp阳性组G-17水平低于Hp阴性组,HSP70水平及SOX-2阳性、HSP70阳性表达率高于Hp阴性组(P<0.05)。Hp阳性患者中,G-17与PG-Ⅰ、PG-Ⅱ呈正相关,与临床症状积分呈负相关,SOX-2、HSP70与PG-Ⅰ、PG-Ⅱ呈负相关,与临床症状积分呈正相关(P<0.05)。Logistic回归分析结果显示,饮食方式、PG-Ⅱ、G-17、SOX-2、HSP70是影响Hp感染胃炎患者的危险因素(P<0.05)。
结论 G-17在Hp感染胃炎患者中水平较低,SOX-2、HSP70阳性表达较高,饮食方式、PG-Ⅱ、G-17、SOX-2、HSP70是影响Hp感染胃炎患者的危险因素。


关键词: 胃炎, 胃泌素17, 性别决定区Y框蛋白2, 热休克蛋白70

Abstract: Objective To investigate the expression and significance of gastrin-17 (G-17), sex-determining region Y box protein-2 (SOX-2), and heat shock protein 70 (HSP70) in Helicobacter pylori (Hp)-infected gastritis. 
Methods Ninety patients with chronic gastritis were selected and divided into Hp-positive group (n=45) and Hp-negative group (n=45) according to whether they were combined with Hp infection. The general data, G-17 and HSP70 levels and SOX-2 and HSP70 expressions of the two groups were compared. The correlation between G-17, SOX-2 and HSP70 in Hp-positive patients with various indexes was analyzed. Multivariate logistic regression analysis was performed to analyze risk factors for Hp-infected gastritis. 
Results The proportion of shared meals and clinical symptom scores in the Hp-positive group were higher than those in the Hp-negative group, and the levels of pepsinogen Ⅰ (PG-Ⅰ) and pepsinogen Ⅱ (PG-Ⅱ) were lower than those in the Hp-negative group (P<0.05). The G-17 level in the Hp-positive group was lower than that in the Hp-negative group, while the expression  level of HSP70, SOX-2 positive and HSP70 positive expression were higher than those in the Hp-negative group (P<0.05). In Hp-positive patients, G-17 was positively correlated with PG-Ⅰ and PG-Ⅱ and negatively correlated with clinical symptom scores, while SOX-2 and HSP70 were negatively correlated with PG-Ⅰ and PG-Ⅱ and positively correlated with clinical symptom scores (P<0.05). The results of logistic regression analysis showed that dietary style, PG-Ⅱ, G-17, SOX-2 and HSP70 were risk factors affecting patients with Hp-infected gastritis (P<0.05). 
Conclusion G-17 is low in patients with Hp-infected gastritis, while positive expression of SOX-2 and HSP70 is higher, and dietary style, PG-Ⅱ, G-17, SOX-2 and HSP70 are risk factors affecting patients with Hp-infected gastritis. 


Key words: gastritis, gastrin-17, sex-determining region Y box protein 2, heat shock protein 70