关键词: 牙种植, 富血小板纤维蛋白, 美学

Abstract: Objective  To investigate the effect of platelet-rich fibrin (PRF) membrane covering the surface of Bio-oss bone graft material on the soft tissue augmentation of dental implants in the aesthetic area of anterior teeth and its aesthetic effect. 
Methods  A total of 80 patients receiving implantation (single tooth) in the aesthetic area of anterior teeth were selected and divided into the control group (n=40) and the research group (n=40) by random number table method. In the control group, the surface of Bio-oss bone graft material was covered with Bio-gide biofilm, and in the research group the surface of Bio-oss bone material was covered with PRF film. Wound healing time in the implantation area, excellent and good rate of implantation, soft tissue increment (increase in width of attached gingiva, increment in thickness of attached gingiva) after implantation, occlusal force, chewing efficiency, inflammatory factors of gingival crevicular fluid ［high sensitivity C-reactive protein (hs-CRP), matrix metalloproteinase-2 (MMP-2), interleukin-6 (IL-6)］ levels, anterior teeth esthetics ［pink ethetic scot (PES), white esthetic score (WES)］ were compared between two groups. 
Results  The wound healing time in the implantation area in the research group was shorter than that of the control group, and the excellent and good rate of implantation was higher than that of the control group (P＜0.05). At 3 months and 6 months after implantation, the increment of gingival width and gingival thickness of the research group was greater than that of the control group, and the difference was statistically significant (P＜0.05). The increment of gingival width and gingival thickness of the research group at 6 months after implantation was greater than that of the control group at 3 months after implantation, and the difference was statistically significant (P＜0.05). At 6 months after implantation, the occlusal force and masticatory efficiency of the two groups were higher than those immediately after implantation, which were higher in the research group than in the control group, and the difference was statistically significant (P＜0.05). At 3 weeks after implantation, hs-CRP, MMP-2, and IL-6 levels in the gingival sulcus fluid of the two groups were lower than those immediately after implantation, which were lower in the research group than in the control group, and the difference was statistically significant (P＜0.05). At 6 months after implantation,the PES and WES scores of the two groups were higher than those immediately after implantation, which were higher in the research group than in the control group, and the difference was statistically significant (P＜0.05). 
Conclusion  PRF membrane covering the surface of Bio-oss bone graft material can more effectively improve the soft tissue increment of dental implant in the esthetic area of anterior teeth, effectively promote the wound healing of the implantation area, improve the excellent and good rate of implantation, and improve the oral function and aesthetic effect of patients. 

Key words: dental implant, platelet-rich fibrin, esthetics