河北医科大学学报 ›› 2024, Vol. 44 ›› Issue (5): 595-600.doi: 10.3969/j.issn.1007-3205.2024.05.018

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创面血管内皮生长因子、血管内皮生长因子受体2水平表达与Ⅱ期肛裂患者术后创面愈合时间的关系研究

  

  1. 上海中医药大学附属曙光医院肛肠科，上海200021

  • 出版日期:2024-05-25 发布日期:2024-05-22
  • 作者简介:陶一秋 (1988-)，女，上海人,上海中医药大学附属曙光医院主治医师,医学硕士，从事肛肠科疾病诊治研究。
  • 基金资助:
    上海市卫生和计划生育委员会项目（ZY（2018-2020）CCCX-1004）；上海中医药大学附属曙光医院四明临床研究专项（SGKJLC-202028）

Relationship of the expression of VEGF and VEGFR-2 in wound with postoperative wound healing time in patients with stage Ⅱ anal fissure wound expression of VEGF and VEGFR-2 and wound healing time after stage Ⅱ anal fissure

  1. Department of Proctology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China

  • Online:2024-05-25 Published:2024-05-22

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摘要： 目的 探讨创面血管内皮生长因子（vascular endothelial growth factor，VEGF）、血管内皮生长因子受体（vascular endothelial growth factor receptor，VEGFR）-2表达与Ⅱ期肛裂术后创面愈合时间的关系。
方法 选取在我院进行手术治疗的Ⅱ期肛裂患者104例为研究对象。术后1周换药时采集创缘肉芽组织检测VEGF、VEGFR-2水平。统计患者术后创面愈合时间，根据患者术后创面愈合时间三分位数分3组，对比3组临床资料及创面VEGF、VEGFR-2水平。分析VEGF、VEGFR-2与术后创面愈合时间的相关性及术后创面愈合时间的影响因素。
结果 3组创面VEGF及VEGFR-2水平比较，差异有统计学意义（P＜0.05）；创面VEGF、VEGFR-2水平愈低，其创面愈合时间愈长（P＜0.05）；VEGF、VEGFR-2与术后创面愈合时间呈负相关（P＜0.05）；便秘、手术时间、开放切口、创面纵径、创面横径为术后创面愈合时间的独立危险因素，VEGF、VEGFR-2均术后创面愈合时间的独立保护因素（P＜0.05）。
结论 创面VEGF、VEGFR-2水平与Ⅱ期肛裂术后创面愈合时间呈负相关，可通过检测两指标水平判断患者创面愈合情况，为术后治疗方案的完善提供指导。


关键词: 肛裂, 血管内皮生长因子受体2, 治疗结果

Abstract: Objective To investigate the relationship of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) expression on the wound surface with postoperative wound healing time in patients with stage Ⅱ anal fissure. 
Methods A total of 104 patients with stage Ⅱ anal fissure who underwent surgical treatment in our hospital were selected as the research subjects. The levels of VEGF and VEGFR-2 collected from the granulation tissue of the wound edge were detected at dressing change at one week after surgery. The postoperative wound healing time of patients was statistically analyzed, and the patients were divided into three groups according to the third percentile of postoperative wound healing time of patients. The clinical data and the levels of VEGF and VEGFR-2 on the wound surface in the three groups were compared. The correlation of VEGF and VEGFR-2 with postoperative wound healing time as well as the influencing factors of postoperative wound healing time was analyzed. 
Results There were significant differences in VEGF and VEGFR-2 levels among the three groups (P＜0.05). The lower the levels of VEGF and VEGFR-2 on the wound surface, the longer the wound healing time (P＜0.05). VEGF and VEGFR-2 were negatively correlated with postoperative wound healing time (P＜0.05). Constipation, duration of operation, open incision, wound longitudinal diameter and wound transverse diameter were independent risk factors for postoperative wound healing time, and VEGF and VEGFR-2 were independent protective factors for postoperative wound healing time (P＜0.05). 
Conclusion The levels of VEGF and VEGFR-2 on the wound surface are negatively correlated with the wound healing time after surgery for stage Ⅱ anal fissure. The two indexes can be used to determine the wound healing of patients, thus providing guidance for the improvement of postoperative treatment plans.  


Key words: anal fissure, vascular endothelial growth factor receptor-2, treatment outcome

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