关键词: 白癜风, 白细胞介素17, 调节性T细胞, 308 nm准分子光

Abstract: Objective To explore the correlation between the detection of serum interleukin-17 (IL-17) and T regulatory cells (Treg) in peripheral blood and the effectiveness of 308 nm excimer light in the treatment of advanced vitiligo. 
Methods In total, 106 patients with advanced vitiligo admitted to Heze Municipal Hospital were selected, and treated with 308 nm excimer light. At 6 months after treatment, they were divided into ineffective group (n=28) and effective group (n=78) according to the therapeutic effect. The levels of serum IL-17 and peripheral blood Treg cells were compared between the two groups. Factors affecting the effectiveness of 308 nm excimer light in the treatment of advanced vitiligo were analyzed. The receiver operating characteristic (ROC) curve was used to analyze the value of serum IL-17 and peripheral blood Treg cell levels in predicting the ineffectiveness of 308 nm excimer light in the treatment of advanced vitiligo. 
Results There was no significant difference between the ineffective group and effective group with respect to gender, age, course of disease, skin lesion area, location of skin lesion, family history, drinking history, onset season, sun exposure, tumor necrosis factor α, interleukin-6, interleukin-23, transforming growth factor β, and immunoglobulin G level (P＞0.05). The constituent ratio of patients with autoimmune diseases and receiving hormone therapy, and serum IL-17 level in ineffective group were higher than those in effective group (P＜0.05), while the level of Treg cells in peripheral blood of patients in ineffective group was lower than that in effective group (P＜0.05). Multivariate logistic regression analysis showed that combined autoimmune diseases, IL-17 and Treg cell levels were independent risk factors that affected the ineffectiveness of 308 nm excimer light in the treatment of advanced vitiligo (P＜0.05). ROC analysis showed that the optimal cutoff points for predicting the ineffectiveness of 308 nm excimer light therapy in advanced vitiligo were 20.04 ng/L and 3.92%, respectively, The sensitivity was 82.14% and 85.71% respectively, and the specificity was 80.77% and 75.64% respectively. The area under the ROC curve (AUC) was 0.889 and 0.829 respectively, and the combined specificity and AUC were 97.44% and 0.940, respectively. 
Conclusion The detection of serum IL-17 and peripheral blood Treg cells are both related to the effectiveness of 308 nm excimer light in the treatment of advanced vitiligo. The clinical detection of serum IL-17 and peripheral blood Treg cells can be used as sensitive indicators to predict the effectiveness of 308 nm excimer light in the treatment of advanced vitiligo, and the combined prediction value of the two is higher. 

Key words: vitiligo； IL-17； Treg cells, 308 nm excimer light