河北医科大学学报 ›› 2024, Vol. 45 ›› Issue (10): 1139-1148.doi: 10.3969/j.issn.1007-3205.2024.10.003

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复合膳食抗氧化指数与6~11岁儿童认知功能的相关性分析

  

  1. 河北医科大学公共卫生学院营养与食品卫生学教研室，河北省环境与人群健康重点实验室，河北 石家庄 050017

  • 出版日期:2024-10-25 发布日期:2024-10-15
  • 作者简介:温瑞（1999-），女，陕西陇县人，河北医科大学医学硕士研究生，从事营养与食品卫生学研究。
  • 基金资助:
    河北省外专引才引智项目（SWZYCYZ202001）

Correlation analysis of composite dietary antioxidant index with cognitive function in children aged 6 to 11 years

  1. Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Key 
    Laboratory of Environment and Human Health of Hebei Province, Shijiazhuang 050017, China

  • Online:2024-10-25 Published:2024-10-15

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摘要： 目的 探讨膳食抗氧化指数（composite dietary antioxidant index，CDAI）与6~11岁儿童认知功能的关系。
方法 基于美国国家健康与营养调查的公开数据（National Health and Nutrition Examination Survey,NHANESⅢ），以及和英国利兹大学合作项目“中国儿童营养不良双重负担及其相关微量营养素缺乏的食物系统解决方案”收集的数据（简称中国数据），构建CDAI，采用多元Logistic回归模型分析6~11岁儿童CDAI水平和认知功能之间的关系。膳食调查分别采用24 h膳食回顾法和24 h膳食称重法，NHANESⅢ采用韦氏智力测验（Wechsler Intelligence Scale for Children,WICS）测试中的语言部分测试（Wide Range Achievement Test-Revised,WRAT-R）和表现测试（Wechsler Intelligence Scale for Children,WISC-R）；中国数据采用基本认知能力测验（Primary Cognitive Abilities Test,PCAT）和WISC-R中的推理测试（perceptual reasoning,PR)。
结果 共纳入470名中国儿童和2 968名美国儿童。在中国儿童中，男性224名，占47.70%，女性246名，占52.30%；在NHANES Ⅲ调查对象中，男性1 494名，占50.30%，女性1 474名，占49.7%。多元Logistics回归分析结果显示，在调整了性别、年龄、种族、体重指数、能量后，6~11岁儿童CDAI是工作记忆（working memory,WM）的影响因素（中国数据：OR=1.04，95%CI：1.00~1.20，P=0.047；NHANES Ⅲ：OR=1.13，95%CI：1.01~1.28，P=0.038）；6~11岁儿童摄入的抗氧化剂中，维生素C、锌摄入量对WM的影响最为显著（中国数据：锌P=0.009，维生素C P=0.030；NHANES Ⅲ：维生素C P=0.040）。
结论 CDAI与儿童认知功能中的WM的影响因素，组成CDAI的各成分中，锌、维生素C的作用更加明显，研究结果提示通过提高膳食抗氧化营养素的摄入，可能会促进儿童工作记忆的发展。


关键词: 复合膳食抗氧化指数, 认知, 儿童

Abstract: Objective To investigate the relationship between the composite dietary antioxidant index (CDAI) and cognitive function in children aged 6 to 11 years. 
Methods CADI was constructed based on the publicly available data from National Health and the Nutrition Examination Survey (NHANES Ⅲ) in the United States, as well as the data collected under a collaborative project with the University of Leeds in the United Kingdom titled "Food System Solutions for the Dual Burden of Malnutrition and Related Trace Nutrient Deficiency in Chinese Children" (referred to as Chinese data). Multiple Logistic regression was used to analyze the association between CDAI levels and cognitive function in children. Dietary surveys were conducted using 24-hour dietary regression and 24-hour dietary weighing methods. NHANES Ⅲ was analyzed using the Wide Range Achievement Test-Revised (WRAT-R) and the Wechsler Intelligence Scale for Children (WISC-R) of the Wechsler Intelligence Scale (WISC-R) test. The Chinese cognitive survey was analyzed using the Primary Cognitive Abilities Test (PCAT) and the perceptual reasoning (PR) of the WISC-R. 
Results A total of 470 Chinese children and 2 968 American children were included. Among Chinese survey respondents, there were 224 males, accounting for 47.70%, and 246 females, accounting for 52.30%. The survey respondents of NHANES Ⅲ included 1 494 males, accounting for 50.30%, and 1 474 females, accounting for 49.7%. After adjusting the covariates of gender, age, race, body mass index (BMI) and energy intake, CDAI was influencing factor of working memory (WM) of children aged 6  to 11 years (the China data: OR=1.04，95%CI： 1.00-1.20，P=0.047; The NHANES Ⅲ data: OR=1.13，95%CI： 1.01-1.28， P=0.038). The WM was significantly and positively associated with vitamin C and zinc intake in children aged 6 to 11 years (the China data: zinc P=0.009, vitamin C P=0.030; The NHANES Ⅲ data: Vitamin C P=0.040). 
Conclusion There is a significant correlation between CDAI and WM in children′s cognitive function, and among the components that make up CDAI, the role of zinc and vitamin C is more pronounced. The results of this study suggest that the development of WM in children can be promoted by increasing the intake of dietary antioxidant nutrients. 


Key words: composite dietary antioxidant index, cognition, children

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