河北医科大学学报 ›› 2025, Vol. 46 ›› Issue (4): 430-435.doi: 10.3969/j.issn.1007-3205.2025.04.010

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双歧杆菌三联活菌联合硫必利治疗对抽动障碍患儿临床症状、免疫功能及肠道菌群的影响

  

  1. 河北省沧州市人民医院儿科，河北 沧州 061000

  • 出版日期:2025-04-25 发布日期:2025-04-17
  • 作者简介:王美玲（1985-），女，河北承德人，河北省沧州市人民医院主治医师，医学学士，从事儿科疾病诊治研究。

  • 基金资助:
    河北省医学科学研究课题计划（20230257）

The effects of Bifidobacterium triple viable combined with thiabendazole treatment on clinical symptoms, immune function and intestinal flora of children with tic disorders

  1. Department of Pediatrics, Cangzhou People′s Hospital, Hebei Province, Cangzhou 061000, China

  • Online:2025-04-25 Published:2025-04-17

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摘要： 目的 观察双歧杆菌三联活菌联合硫必利治疗对抽动障碍患儿临床症状、免疫功能及肠道菌群的影响。
方法 选取2021年3月—2023年3月在河北省沧州市人民医院儿科收治的抽动障碍患儿104例，采用随机数字表法分为对照组和观察组，对照组给予盐酸硫必利治疗，观察组给予双歧杆菌三联活菌联合硫必利治疗。比较2组治疗前后耶鲁全球抽动严重程度量表（Yale Global Tic Severity Scale，YGTSS）评分、神经功能评分量表（American Spinal Injury Association，ASIA）评分、免疫功能、肠道菌群α多样性。统计2组不良反应发生率。
结果 治疗前，2组各个指标差异均无统计学意义（P＞0.05）。治疗12周后，2组运动抽动、发声抽动、社会功能缺损、YGTSS总分低于治疗前，ASIA评分中运动和感觉评分、CD3+、CD3+CD4+、CD4+/CD8+、Shannon指数、Chao1指数、Sobs指数、Ace指数高于治疗前，观察组运动抽动、发声抽动、社会功能缺损、YGTSS总分低于对照组，ASIA评分中运动和感觉评分、CD3+、CD3+CD4+、CD4+/CD8+、Shannon指数、Chao1指数、Sobs指数、Ace指数高于对照组，差异有统计学意义（P＜0.05）。观察组总有效率［94.23%（49/52）］高于［80.77%（42/52）］对照组，差异有无统计学意义（P＜0.05）。2组头晕、胃肠道不适、食欲不振、嗜睡等不良反应发生率比较［13.46%(7/52) vs. 3.85%（3/52）］差异无统计学意义（P＞0.05）。
结论 双歧杆菌三联活菌联合硫必利治疗儿童抽动障碍可调节免疫功能，改善肠道菌群α多样性，修复受损神经功能。


关键词: 抽搐性运动障碍, 双歧杆菌三联活菌, 硫必利

Abstract: Objective To observe the effects of Bifidobacterium triple viable combined with thiabendazole treatment on clinical symptoms, immune function and intestinal flora of children with tic disorders. 
 Methods In total, 104 children with tic disorders admitted to the Department of Paediatrics of Cangzhou People′s Hospital in Hebei Province from March 2021 to March 2023 were selected and divided into the control group and the observation group using the random number table method. The control group was given thiabendazole hydrochloride, and the observation group was given Bifidobacterium triple viable combined with thiabendazole. The Yale Global Tic Severity Scale (YGTSS) score, American Spinal Injury Association (ASIA) score, immune function, and α diversity of intestinal flora before and after treatment were compared between the two groups. The incidence of adverse reactions in the two groups was calculated. 
 Results Before treatment, the differences in each index between the two groups were not statistically significant (P＞0.05). At 12 weeks after treatment, the total scores of motor tics, vocal tics, social function deficits, and YGTSS of the two groups were lower than those before treatment, while the motor and sensory scores of the ASIA score, CD3+, CD3+CD4+, CD4+/CD8+, Shannon index, Chao1 index, Sobs index, and Ace index were higher than those before treatment. The total scores of motor tics, vocal tics, social function deficits, and YGTSS of the observation group were lower than those of the control group, while the motor and sensory scores of the ASIA score, CD3+, CD3+CD4+, CD4+/CD8+, Shannon index, Chao1 index, Sobs index, and Ace index were higher than those of the control group, showing significant differences (P＜0.05). The total effective rate of the observation group ［94.23% (49/52)］ was higher than that of the control group ［80.77% (42/52)］, suggesting no significant difference (P＜0.05). The incidence rates of adverse reactions, such as dizziness, gastrointestinal discomfort, loss of appetite, and drowsiness, between the two groups ［13.46% (7/52) vs. 3.85% (3/52)］ showed no significant difference (P＞0.05). 
 Conclusion Bifidobacterium triple viable combined with thiabendazole in the treatment of children with tic disorders regulates immune function, improves the α diversity of the intestinal flora, and repairs damaged neurological function. 


Key words: tic disorders, Bifidobacterium triple viable, thiabendazole ,  ,

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